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Volume 12, Number 2—February 2006
Perspective

Antimicrobial Drug Resistance, Regulation, and Research1

Joshua P. Metlay*†Comments to Author , John H. Powers‡, Michael N. Dudley§, Keryn Christiansen¶, Roger G. Finch#**, on behalf of the Second Colloquium of the International Forum on Antibiotic Resistance
Author affiliations: *VA Medical Center, Philadelphia, Pennsylvania, USA; †University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA; ‡US Food and Drug Administration, Rockville, Maryland, USA; §Diversa Corporation, San Diego, California, USA; ¶Royal Perth Hospital, Perth, Western Australia, Australia; #Nottingham City Hospital, Nottingham, United Kingdom; **University of Nottingham, Nottingham, United Kingdom

Main Article

Figure 4

Relationship between the dominant pharmacokinetic/pharmacodynamic (PK/PD) index, efficacy, and resistance emergence in vitro (both quantified by the number of bacterial colony-forming units). The PK/PD index is related to efficacy in a sigmoid curve and the resistance emergence by an inverted U-shaped curve (21).

Figure 4. Relationship between the dominant pharmacokinetic/pharmacodynamic (PK/PD) index, efficacy, and resistance emergence in vitro (both quantified by the number of bacterial colony-forming units). The PK/PD index is related to efficacy in a sigmoid curve and the resistance emergence by an inverted U-shaped curve (21).

Main Article

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Main Article

1This article is based on presentations and discussions held at the Second Colloquium of the International Forum on Antibiotic Resistance (IFAR), held on September 13, 2003, in Chicago, Illinois, USA. IFAR is a multidisciplinary, international group concerned with evaluating current knowledge regarding antimicrobial drug resistance and the means for its control. This article represents the opinions of the participants at the second IFAR colloquium and not necessarily those of the institutions for whom they work.

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The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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