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Volume 12, Number 2—February 2006

Perspective

HIV Drug-resistant Strains as Epidemiologic Sentinels

María S. Sánchez*Comments to Author , Robert M. Grant†, Travis C. Porco‡, and Wayne M. Getz*
Author affiliations: *University of California, Berkeley, California, USA; †Gladstone Institute of Virology and Immunology, San Francisco, California, USA; ‡California Department of Health Services, Berkeley, California, USA

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Table

Impact of an increase in high-risk behavior, decrease in the fraction of acute HIV infected persons receiving treatment, and increase in treatment efficacy on the primary resistant fraction, disease, and resistance prevalence in the overall population

Cause Effect
Primary resistant fraction Disease prevalence Resistance prevalence
Increase in high-risk behavior Temporary decrease Permanent increase Permanent increase
Decrease in fraction acute treated Permanent decrease Permanent increase Permanent decrease
Increase in treatment efficacy Permanent decrease Permanent decrease Permanent decrease

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