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Volume 12, Number 3—March 2006

Research

Chemoprophylaxis and Malaria Death Rates

Gérard Krause*Comments to Author , Irene Schöneberg*, Doris Altmann*, and Klaus Stark*
Author affiliations: *Robert Koch-Institute, Berlin, Germany

Main Article

Table 1

Univariate analysis of risk factors for fatal outcome of imported Plasmodium falciparum malaria in nonimmune patients, Germany 1993–2004

Risk factor Odds ratio 95% confidence interval p value
Chemoprophylaxis, total (n = 3,752)
No 1
Yes 0.743 0.493-1.121 0.157
Chemoprophylaxis, comparison of regimens (n = 3,752) 0.047
None (n = 2,171) 1
Chloroquine alone (n = 485) 1.372 0.824-2.285 0.225
Proguanil alone (n = 59) 0.550 0.075-4.030 0.556
Mefloquine alone (n = 322) 0.503 0.201-1.258 0.142
Chloroquine plus proguanil (n = 459) 0.280 0.102-0.773 0.014
Other (n = 256)* 0.765 0.328-1.784 0.536
Compliance of chemoprophylaxis (n = 3717) 0.293†
No chemoprophylaxis 1
Chemoprophylaxis with incomplete or unknown compliance 0.829 0.535-1.284 0.401
Chemoprophylaxis complete 0.538 0.231-1.249 0.149
Age (n = 3,844)
Continuously (by year) 1.055 1.040-1.070 <0.001
Sex (n = 3,901)
Female 1
Male 1.141 0.768-1.695 0.515
Country of infection in Africa (n = 3,832)
No 1
Yes 3.642 1.150-11.529 0.028
Reporting year (n = 3,935) 0.004†

*235 were combinations of drugs that are not officially recommended regimens, 15 were doxycycline alone, and 6 were atovaquone/proguanil.
†Overall p value for the categoric variable.

Main Article

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