Skip directly to search Skip directly to A to Z list Skip directly to site content
CDC Home

Volume 12, Number 5—May 2006
THEME ISSUE
Tuberculosis Special Section

Research

Mycobacterium tuberculosis and Rifampin Resistance, United Kingdom

I-Ching Sam*1, Francis Drobniewski*Comments to Author , Philip More*, Melanie Kemp*, and Timothy Brown*
Author affiliations: *Health Protection Agency, London, United Kingdom

Main Article

Table 2

Results of LiPA in detecting rifampin resistance in specimens from which MTBC was correctly identified and cultured*

Sample and AFB smear result No. positive/no. tested (%)
Concordance Sensitivity Specificity PPV NPV Mean days saved
All primary LiPA 775/782 (99.1) 38/40 (95.0) 737/740 (99.6) 38/41 (92.7) 738/740 (99.7) 30.7
Positive 743/747 (99.5) 35/36 (97.2) 708/710 (99.7) 35/37 (94.6) 709/710 (99.9) 30.4
Negative 32/35 (91.4) 3/4 (75.0) 29/30 (96.7) 3/4 (75.0) 29/30 (96.7) 37.2
Not done
Respiratory 669/672 (99.6) 32/33 (97.0) 637/639 (99.7) 32/34 (94.1) 637/638 (99.8) 30.4
Positive 654/657 (99.5) 31/32 (96.9) 623/625 (99.7) 31/33 (93.9) 623/624 (99.8) 30.2
Negative 15/15 (100.0) 1/1 (100.0) 14/14 (100.0) 1/1 (100.0) 14/14 (100.0) 39.1
Not done
Nonrespiratory 106/110 (96.4) 6/7 (85.7) 100/101 (99.0) 6/7 (85.7) 101/102 (99.0) 32.5
Positive 89/90 (98.9) 4/4 (100.0) 85/85 (100.0) 4/4 (100.0) 86/86 (100.0) 32.0
Negative 17/20 (85.0) 2/3 (66.7) 15/16 (93.8) 2/3 (66.7) 15/16 (93.8) 35.5
Not done
Clinical isolate 229/235 (97.4) 21/23 (91.3) 208/211 (98.6) 21/24 (87.5) 208/210 (99.0) 16.3

*LiPA, line probe assay; MTBC, Mycobacterium tuberculosis complex; AFB, acid-fast bacilli; PPV, positive predictive value; NPV, negative predictive value.

Main Article

1Current affiliation: University of Malaya, Kuala Lumpur, Malaysia

Top of Page

USA.gov: The U.S. Government's Official Web PortalDepartment of Health and Human Services
Centers for Disease Control and Prevention   1600 Clifton Rd. Atlanta, GA 30333, USA
800-CDC-INFO (800-232-4636) TTY: (888) 232-6348 - Contact CDC–INFO