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Volume 12, Number 5—May 2006
THEME ISSUE
Tuberculosis Special Section

Research

Mycobacterium tuberculosis and Rifampin Resistance, United Kingdom

I-Ching Sam*1, Francis Drobniewski*Comments to Author , Philip More*, Melanie Kemp*, and Timothy Brown*
Author affiliations: *Health Protection Agency, London, United Kingdom

Main Article

Table 5

Results of LiPA in detecting MTBC in clinical specimens in which MTBC was correctly identified and cultured, stratified by history of antituberculous treatment*

Treatment history/AFB smear result No. positive/no. tested (%)
Concordance Sensitivity Specificity PPV NPV
Current or within 3 mo 86/182 (47.3) 48/67 (71.6) 38/115 (33.0) 48/125 (38.4) 38/57 (66.7)
Positive 61/132 (46.2) 46/55 (83.6) 15/77 (19.5) 46/108 (42.6) 15/24 (62.5)
Negative/not done 25/50 (50.0) 2/12 (16.7) 23/38 (60.5) 2/17 (11.8) 23/33 (69.7)
Adjusted values† 86/139 (61.9) 48/67 (71.6) 38/72 (52.8) 48/82 (58.5) 38/57 (66.7)
Positive 61/99 (61.6) 46/55 (83.6) 15/44 (34.1) 46/75 (61.3) 15/24 (62.5)
Negative/not done 25/40 (62.5) 2/12 (16.7) 23/28 (82.1) 2/7 (28.6) 23/33 (69.7)
>3 mo ago 85/106 (80.2) 42/53 (79.2) 43/53 (81.1) 42/52 (80.8) 43/54 (79.6)
Positive 54/65 (83.1) 40/45 (88.9) 14/20 (70.0) 40/46 (87.0) 14/19 (73.7)
Negative/not done 31/41 (75.6) 2/8 (25.0) 29/33 (87.9) 2/6 (33.3) 29/35 (82.9)
Adjusted values† 85/102 (83.3) 42/53 (79.2) 43/49 (87.8) 42/48 (87.5) 43/54 (79.6)
Positive 54/63 (85.7) 40/45 (88.9) 14/18 (90.9) 40/44 (90.9) 14/19 (73.7)
Negative/not done 31/39 (79.5) 2/8 (25.0) 29/31 (93.5) 2/4 (50.0) 29/35 (82.5)
No stated treatment 1,497/1,634 (91.6) 692/798 (86.7) 805/836 (96.3) 692/723 (95.7) 805/911 (88.4)
Positive 845/902 (93.7) 661/698 (94.7) 184/204 (90.2) 661/681 (97.1) 184/221 (83.3)
Negative/not done 652/732 (89.1) 31/100 (31.0) 621/632 (98.3) 21/42 (73.8) 621/690 (90.0)
Adjusted values† 1,497/1,634 (91.6) 692/798 (86.7) 805/836 (96.3) 692/723 (95.7) 805/911 (88.4)
Positive 845/892 (94.7) 661/698 (94.7) 184/194 (94.8) 661/671 (98.5) 184/221 (83.3)
Negative/not done 652/728 (89.6) 31/100 (31.0) 621/628 (98.9) 31/38 (81.6) 621/690 (90.0)

*LiPA, line probe assay; MTBC, Mycobacterium tuberculosis complex; AFB, acid-fast bacilli; PPV, positive predictive value; NPV, negative predictive value.
†Excludes samples from patients with a microbiologic diagnosis of MTBC made at the Mycobacterium Reference Unit in the last 18 or subsequent 3 months.

Main Article

1Current affiliation: University of Malaya, Kuala Lumpur, Malaysia

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