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Volume 12, Number 5—May 2006
THEME ISSUE
Tuberculosis Special Section

Research

Mycobacterium tuberculosis and Rifampin Resistance, United Kingdom

I-Ching Sam*1, Francis Drobniewski*Comments to Author , Philip More*, Melanie Kemp*, and Timothy Brown*
Author affiliations: *Health Protection Agency, London, United Kingdom

Main Article

Table 7

Sequence analysis of 10 discrepant rifampin-susceptibility results*

Sample no. Rifampin susceptibility
LiPA result Phenotypic result Conclusion after sequencing
1–3 Sensitive Resistant From the same patient; wild-type rpoB test region
4 Sensitive Resistant Mycobacterium bovis; wild-type rpoB test region
5–7 Resistant (DS4) Sensitive From the same patient; synonymous substitution (R528R) not associated with rifampin resistance
8 Resistant (DS1) Sensitive 2 genotypes present: wild-type (predominant) and mutant (L511P)
9 Resistant (R5) Sensitive S531L mutation; wild-type rpoB on retesting, thus likely laboratory error
10 Resistant (DS2) Sensitive D516A mutation; no high-level resistance when seen alone

*LiPA, line probe assay.

Main Article

1Current affiliation: University of Malaya, Kuala Lumpur, Malaysia

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