Isoniazid Preventive Therapy and Risk for Resistant Tuberculosis
Figure 2. Funnel plots to detect publication bias for studies reporting the effect of isoniazid preventive therapy on risk for isoniazid-resistant tuberculosis. The log relative risk (RR) for each study is plotted against the standard error of the natural log (ln) of the RR. The horizontal line indicates the (log) summary RR, and guidelines to assist in visualizing the funnel are plotted at the 95% pseudoconfidence limits about the summary RR estimate. A) Using definition (a) of resistance for the Greenland study (20); B) using definition (b) of resistance for the Greenland study.