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Volume 12, Number 5—May 2006
THEME ISSUE
Tuberculosis Special Section

Research

Isoniazid Preventive Therapy and Risk for Resistant Tuberculosis

Maria Elvira Balcells*1, Sara L. Thomas*, Peter Godfrey-Faussett*, and Alison D. Grant*Comments to Author 
Author affiliations: *London School of Hygiene and Tropical Medicine, London, United Kingdom

Main Article

Figure 2

Funnel plots to detect publication bias for studies reporting the effect of isoniazid preventive therapy on risk for isoniazid-resistant tuberculosis. The log relative risk (RR) for each study is plotted against the standard error of the natural log (ln) of the RR. The horizontal line indicates the (log) summary RR, and guidelines to assist in visualizing the funnel are plotted at the 95% pseudoconfidence limits about the summary RR estimate. A) Using definition (a) of resistance for the Greenla

Figure 2. Funnel plots to detect publication bias for studies reporting the effect of isoniazid preventive therapy on risk for isoniazid-resistant tuberculosis. The log relative risk (RR) for each study is plotted against the standard error of the natural log (ln) of the RR. The horizontal line indicates the (log) summary RR, and guidelines to assist in visualizing the funnel are plotted at the 95% pseudoconfidence limits about the summary RR estimate. A) Using definition (a) of resistance for the Greenland study (20); B) using definition (b) of resistance for the Greenland study.

Main Article

1Current affiliation: Department of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile

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