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Volume 12, Number 5—May 2006
THEME ISSUE
Tuberculosis Special Section

Research

Tuberculosis Transmission Attributable to Close Contacts and HIV Status, Malawi

Amelia C. Crampin*†, Judith R. Glynn*Comments to Author , Hamidou Traore*, Malcolm D. Yates‡, Lorren Mwaungulu†, Michael Mwenebabu†, Steven D. Chaguluka†, Sian Floyd*, Francis Drobniewski‡, and Paul E.M. Fine*
Author affiliations: *London School of Hygiene and Tropical Medicine, London, United Kingdom; †Karonga Prevention Study, Chilumba, Malawi; ‡Health Protection Agency National Mycobacterium Reference Laboratory, London, United Kingdom

Main Article

Table 1

Comparison of Mycobacterium tuberculosis strains of index cases and putative source contacts (PSCs)

Comparison of strains, no. (%)
Identical 1–4 bands different and first example of new strain 1–4 bands different and not first example >4 bands different Total
Total 51 (25.5) 8 (4.0) 15 (7.5) 126 (63.0) 200
Source of linking information
Database only 9 (25.7) 1 (2.9) 5 (14.3) 20 (57.1) 35
History only 14 (16.5) 4 (4.7) 6 (7.1) 61 (71.8) 85
Both 28 (35.0) 3 (3.8) 4 (5.0) 45 (56.3) 80
Characteristic of PSC in case-PSC pairs
Smear-positive pulmonary 48 (28.7) 7 (4.2) 15 (9.0) 97 (58.1) 167
Smear-negative pulmonary 2 (9.1) 1 (4.6) 0 (0.0) 19 (86.4) 22
Extrapulmonary 1 (9.1) 0 (0.0) 0 (0.0) 10 (90.9) 11
No. bands in RFLP* of PSC
<5 6 (40.0) 1 (6.7) 0 (0.0) 8 (53.3) 15
5–10 17 (22.7) 6 (8.0) 8 (10.7) 44 (58.7) 75
>10 28 (25.5) 1 (0.9) 7 (6.4) 74 (67.3) 110

*RFLP, restriction fragment length polymorphism.

Main Article

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