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Volume 12, Number 5—May 2006

Letter

Extended-spectrum β-Lactamase–producing Enterobacteriaceae, Central African Republic

Thierry Frank*, Guillaume Arlet†‡Comments to Author , Valerie Gautier†, Antoine Talarmin*, and Raymond Bercion*
Author affiliations: *Institut Pasteur de Bangui, Bangui, Central African Republic; †Université Pierre et Marie Curie (Paris VI), Paris, France; ‡Hôpital Tenon AP-HP, Paris, France

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Table

Characteristics of extended-spectrum β-lactamase–producing Enterobacteriaceae in Bangui, Central African Republic

Strain† Patient hospitalized Results of sequencing
MICs of β-lactams (μg/mL)*
blaCTX-M blaSHV blaTEM AMC CTX CAZ CRO FEP CPO ATM Resistance
K. pneumoniae 022 N SHV-2a TEM-1 16 16 16 16 8 8 2 KGT
K. pneumoniae 043 Y SHV-12 TEM-1 16 16 256 32 8 8 256 KGTNC
K. pneumoniae 106 Y CTX-M-15 TEM-1 8 256 128 256 64 256 64 None
K. pneumoniae 047 Y SHV-2a TEM-1 64 16 16 16 8 16 32 None
E. coli 272 Y CTX-M-15 TEM-1 32 256 128 256 128 256 128 KGTNC
E. coli 065 Y CTX-M-15 TEM-1 20 256 128 256 64 256 128 C
E. coli 047 N CTX-M-15 TEM-1 16 256 32 256 32 128 64 KGTC
E. coli 010 N CTX-M-15 TEM-1 32 256 128 256 128 256 256 KGT
E. coli 073 N CTX-M-15 TEM-1 16 256 128 256 128 256 128 KGTC
E. coli 059 Y CTX-M-15 TEM-1 19 256 128 256 8 256 256 C
E. coli 064 N CTX-M-15 TEM-1 128 256 128 256 64 256 64 C
E. coli 070 N CTX-M-15 TEM-1 128 256 128 256 64 256 128 C
E. coli 054 N CTX-M-15 TEM-1 128 256 32 256 64 256 32 KGTC
E. coli 026 N CTX-M-15 TEM-1 32 256 64 256 128 256 256 KGTC
E. cloacae 081 Y SHV-12 TEM-1 32 16 256 16 0.125 1 256 KGTN
E. cloacae 106 Y SHV-12 TEM-1 128 16 256 16 32 8 256 KGT
E. aerogenes 014 Y CTX-M-3 SHV-12 TEM-1 128 256 256 256 32 256 128 KGTN

*AMC, amoxicillin + clavulanic acid (2 μg/mL); CTX, cefotaxime; CAZ, ceftazidime; CRO, ceftriaxone; FEP, cefepime; CPO, cefpirome; ATM, aztreonam; K, kanamycin; G, gentamicin; T, tobramycin; N, netilmicin; C, ciprofloxacin.
†On Klebsiella pneumoniae strains, polymerase chain reaction and sequencing for blaSHV genes were studied on Escherichia coli transconjugant or electroporant.

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