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Volume 12, Number 5—May 2006

Dispatch

Heterogeneity among Mycobacterium ulcerans Isolates from Africa

Pieter Stragier*, Anthony Ablordey*, L. Manou Bayonne†, Yatta L. Lugor‡, Ireneaus S. Sindani§, Patrick Suykerbuyk*, Henry Wabinga¶, Wayne M. Meyers#, and Françoise Portaels*Comments to Author 
Author affiliations: *Institute of Tropical Medicine, Antwerp, Belgium; †Centre Hospitalier de Libreville, Libreville, Gabon; ‡Yambio Hospital, Eldoret, Kenya; §World Health Organization South Sudan Office, Gigiri, Nairobi, Kenya; ¶Makerere University, Kampala, Uganda; #Armed Forces Institute of Pathology, Washington, DC, USA

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Table 1

MIRU-VNTR profiles of Mycobacterium ulcerans and origin of specimens (BK no.) or culture isolates*

ITM no./loci† 1‡ 6‡ 9‡ 33‡ Genotype Origin Ziehl-Neelsen staining§ Year¶
5142 1 1 1 2 Victoria Victoria, Australia 1967
9540 1 1 1 3 Southeast Asia Queensland, Australia; PNG; Malaysia 1978
98-0912, 8756 1 2 1 3 Asia China, Japan 1998
BK03-0621 2 1 1 3 PNGII PNG 3+ 2003
BK02-2487 2 1 1 1 PNGIII PNG 1+ 2002
BK04-0296 2 1 1 1 PNG 1+ 2004
842 NA 1 2 1 Suriname Suriname 1984
7922 2 2 2 1 French Guiana French Guiana 1990
5114 1 2 2 1 Mexico Mexico 1953
5116 1 2 2 2 Central African Congo River Basin Maniema, DRC 1962
9099 1 2 2 2 Maniema, DRC 1964
5150 3 1 1 3 Atlantic Africa Bas-Congo, DRC 1962
94-0662 3 1 1 3 Côte d'Ivoire 1994
96-0658 3 1 1 3 Angola 1996
97-0483 3 1 1 3 Ghana 1997
BK04-0875 3 1 1 3 Togo 4+ 2004
BK04-1396 3 1 1 3 Benin 2004
02-0280 3 1 1 3 Cameroon 2002
02-1081 3 1 1 3 Cameroon 2002
05-0303 3 1 1 3 Congo-Brazzaville 1979
05-0304 3 1 1 3 Congo-Brazzaville 1979
BK05-0027 3 1 1 3 Gabon 1+ 2005
BK04-1591 4 1 1 1 East African Nile River Basin Sudan 4+ 2004
BK04-1601 4 1 1 1 Sudan 2004
05-0861 4 1 1 1 Orientale, DRC 1959
05-1459 4 1 1 1 Uganda (NCTC no. 10445) 1964
BK04-0513 4 1 1 1 Uganda 1+ 2004
BK05-0614 4 1 1 1 Uganda 4+ 2005

*MIRU, mycobacterial interspersed repetitive unit; VNTR, variable-number tandem repeat; PNG, Papua New Guinea; DRC, Democratic Republic of Congo; NA, no amplification; NCTC, National Collection of Type Cultures. Shaded fields represent results from our previous study (6).
†ITM numbers (Institute of Tropical Medicine). These numbers are representative members for the genotype each belongs to (6).
‡Numbers in columns 2 through 5 represent the number of repeats at the specific locus. These numbers form a pattern that divides M. ulcerans into genotypes.
§Scale of the American Thoracic Society. Ziehl-Neelsen staining has not been done on culture isolates, since identifying acid-fast bacilli in a culture is an obsolete practice.
¶The date represents the year of isolation.

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