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Volume 12, Number 5—May 2006


Coronavirus HKU1 Infection in the United States

Frank Esper*, Carla Weibel†, David Ferguson†, Marie L. Landry†, and Jeffrey S. Kahn†Comments to Author 
Author affiliations: *Case Western Reserve University School of Medicine, Cleveland, Ohio, USA; †Yale University School of Medicine, New Haven, Connecticut, USA

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Clinical manifestations associated with human coronavirus HKU1 infection*

Patient no. (sex) Age (mo) Specimen collection date Length of hospitalization (d) Diagnosis Underlying illness Signs/symptoms Chest radiographic findings
1 (M) 4 Dec 18 1 New onset seizures RAD Rhinorrhea, cough Not obtained
2 (M) 12 Dec 20 4 Pneumonia Cystic fibrosis Fever, rhinorrhea, cough, wheezing, rhonchi, retractions, rash Infiltrates
3 (F)†‡ 1 Dec 22, 31 9 Pneumonia None Fever, hypoxia, rhinorrhea, cough, wheezing, rhonchi, retractions, nasal flaring, apnea Hyperinflation, infiltrates, peribronchial cuffing, atelectasis
4 (M) 2 Jan 5 NH Fever None Fever, rhinorrhea Not obtained
5 (F)† 20 Jan 14, 16 2 ALTE None Fever, rhinorrhea, cough Infiltrates, atelectasis
6 (F) 3 Jan 16 NH Bronchiolitis Prematurity (34 weeks) Rhinorrhea, cough, wheezing, rhonchi Peribronchial cuffing
7 (M) 13 Jan 19 10 Hepatitis Biliary atresia, liver transplantation Rhinorrhea, rhonchi, abnormal LFT results Not obtained
8 (F) 16 Jan 19 1 Fever Sickle cell anemia Fever, rhinorrhea Not obtained
9 (F) 13 Feb 1 NH Fever None Fever, rhinorrhea, cough Not obtained

*M, male; F, female; RAD, reactive airway disease; NH, not hospitalized; ALTE, apparent life-threatening event; LFT, liver function tests (aspartate aminotransferase 238 U/mL, alanine aminotransferase 373 U/mL, alkaline phosphatase 406 U/mL, bilirubin [total/direct] 0.15/0.05 mg/dL).
†Two respiratory specimens tested positive for human coronavirus HKU1.
‡Patient required mechanical ventilation and admission to the pediatric intensive care unit.

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