Volume 12, Number 5—May 2006
Research
Coronavirus HKU1 Infection in the United States
Frank Esper*, Carla Weibel†, David Ferguson†, Marie L. Landry†, and Jeffrey S. Kahn†
Table
Clinical manifestations associated with human coronavirus HKU1 infection*
| Patient no. (sex) | Age (mo) | Specimen collection date | Length of hospitalization (d) | Diagnosis | Underlying illness | Signs/symptoms | Chest radiographic findings |
|---|---|---|---|---|---|---|---|
| 1 (M) | 4 | Dec 18 | 1 | New onset seizures | RAD | Rhinorrhea, cough | Not obtained |
| 2 (M) | 12 | Dec 20 | 4 | Pneumonia | Cystic fibrosis | Fever, rhinorrhea, cough, wheezing, rhonchi, retractions, rash | Infiltrates |
| 3 (F)†‡ | 1 | Dec 22, 31 | 9 | Pneumonia | None | Fever, hypoxia, rhinorrhea, cough, wheezing, rhonchi, retractions, nasal flaring, apnea | Hyperinflation, infiltrates, peribronchial cuffing, atelectasis |
| 4 (M) | 2 | Jan 5 | NH | Fever | None | Fever, rhinorrhea | Not obtained |
| 5 (F)† | 20 | Jan 14, 16 | 2 | ALTE | None | Fever, rhinorrhea, cough | Infiltrates, atelectasis |
| 6 (F) | 3 | Jan 16 | NH | Bronchiolitis | Prematurity (34 weeks) | Rhinorrhea, cough, wheezing, rhonchi | Peribronchial cuffing |
| 7 (M) | 13 | Jan 19 | 10 | Hepatitis | Biliary atresia, liver transplantation | Rhinorrhea, rhonchi, abnormal LFT results | Not obtained |
| 8 (F) | 16 | Jan 19 | 1 | Fever | Sickle cell anemia | Fever, rhinorrhea | Not obtained |
| 9 (F) | 13 | Feb 1 | NH | Fever | None | Fever, rhinorrhea, cough | Not obtained |
*M, male; F, female; RAD, reactive airway disease; NH, not hospitalized; ALTE, apparent life-threatening event; LFT, liver function tests (aspartate aminotransferase 238 U/mL, alanine aminotransferase 373 U/mL, alkaline phosphatase 406 U/mL, bilirubin [total/direct] 0.15/0.05 mg/dL).
†Two respiratory specimens tested positive for human coronavirus HKU1.
‡Patient required mechanical ventilation and admission to the pediatric intensive care unit.
