Volume 12, Number 6—June 2006
Dispatch
Guillain-Barré Syndrome, Greater Paris Area
Valérie Sivadon-Tardy*
, David Orlikowski*, Flore Rozenberg†, Christiane Caudie‡, Tarek Sharshar*, Pierre Lebon†, Djillali Annane*, Jean-Claude Raphaël*, Raphaël Porcher§, and Jean-Louis Gaillard*
, David Orlikowski*, Flore Rozenberg†, Christiane Caudie‡, Tarek Sharshar*, Pierre Lebon†, Djillali Annane*, Jean-Claude Raphaël*, Raphaël Porcher§, and Jean-Louis Gaillard*
Table
Characteristics of patients with Guillain-Barré syndrome*
| Characteristic | All patients | Campylobacter jejuni | CMV | Unknown agent | p value† | p value‡ |
|---|---|---|---|---|---|---|
| No. | 263 | 58 | 40 | 157 | ||
| Sex, no. (%) | 0.53 | 0.31 | ||||
| Female | 112 (43) | 21 (36) | 22 (55) | 66 (42) | ||
| Male | 151 (57) | 37 (64) | 18 (45) | 91 (58) | ||
| Mean age, y (SD) | 48.7 (18.3) | 51.3 (19.1) | 35.9 (12.0) | 51.2 (17.9) | 0.94 | <0.0001 |
| Mean days from infectious event to neurologic signs (IQR) | 8 (4–15) | 7 (4–14.2) | 10 (4.5–18) | 8 (5–15) | 0.45 | 0.55 |
| Mean days from neurologic signs to hospital admission (IQR) | 5.5 (3–9) | 4 (2.5–7 | 7 (3–11) | 6 (3–10) | 0.11 | 0.27 |
| Infectious event, no. (%) | 0.0048 | 0.25 | ||||
| None | 99 (38) | 13 (22) | 14 (35) | 73 (47) | ||
| >1 | 164 (62) | 45 (78) | 26 (65) | 84 (53) | ||
| Infectious event, no. (%) | 0.0049 | 0.026 | ||||
| GI | 61 (37) | 30 (67) | 3(11) | 27 (31) | ||
| URTI | 37 (23) | 6 (13) | 9 (35) | 21 (25) | ||
| LRTI | 29 (12) | 2 (4) | 1 (4) | 12 (14) | ||
| Influenzalike | 30 (18) | 5 (11) | 6 (23) | 18 (21) | ||
| Others | 16 (10) | 2 (4) | 7 (27) | 6 (7) | ||
| Only motor symptoms, no. (%) | 101 (39) | 31 (54) | 11 (28) | 57 (37) | 0.056 | 0.35 |
| Mechanical ventilation, no. (%) | 87 (33) | 23 (40) | 15 (38) | 43 (27) | 0.20 | 0.49 |
| Antibodies to gangliosides, no. (%) | ||||||
| GM1 | 30 (13) | 24 (44) | 0 | 5 (4) | <0.0001 | 0.59 |
| GM2 | 15 (6) | 0 | 15 (47) | 0 | 1.0 | <0.0001 |
*CMV, cytomegalovirus; SD, standard deviation, IQR, interquartile range; GI, gastrointestinal illness; URTI, upper respiratory tract infection; LRTI, lower respiratory tract infection.
†Adjusted for unknown agent versus C. jejuni.
‡Adjusted for unknown agent versus CMV.
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