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Volume 12, Number 6—June 2006

Dispatch

Guillain-Barré Syndrome, Greater Paris Area

Valérie Sivadon-Tardy*Comments to Author , David Orlikowski*, Flore Rozenberg†, Christiane Caudie‡, Tarek Sharshar*, Pierre Lebon†, Djillali Annane*, Jean-Claude Raphaël*, Raphaël Porcher§, and Jean-Louis Gaillard*
Author affiliations: *Hôpital Raymond Poincaré, Garches, France; †Hôpital Saint-Vincent-de-Paul, Paris, France; ‡Hôpital Neurologique et Neurochirurgical Pierre Wertheimer, Lyon, France; §Hôpital Saint-Louis, Paris, France

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Table

Characteristics of patients with Guillain-Barré syndrome*

Characteristic All patients Campylobacter jejuni CMV Unknown agent p value† p value‡
No. 263 58 40 157
Sex, no. (%) 0.53 0.31
Female 112 (43) 21 (36) 22 (55) 66 (42)
Male 151 (57) 37 (64) 18 (45) 91 (58)
Mean age, y (SD) 48.7 (18.3) 51.3 (19.1) 35.9 (12.0) 51.2 (17.9) 0.94 <0.0001
Mean days from infectious event to neurologic signs (IQR) 8 (4–15) 7 (4–14.2) 10 (4.5–18) 8 (5–15) 0.45 0.55
Mean days from neurologic signs to hospital admission (IQR) 5.5 (3–9) 4 (2.5–7 7 (3–11) 6 (3–10) 0.11 0.27
Infectious event, no. (%) 0.0048 0.25
None 99 (38) 13 (22) 14 (35) 73 (47)
>1 164 (62) 45 (78) 26 (65) 84 (53)
Infectious event, no. (%) 0.0049 0.026
GI 61 (37) 30 (67) 3(11) 27 (31)
URTI 37 (23) 6 (13) 9 (35) 21 (25)
LRTI 29 (12) 2 (4) 1 (4) 12 (14)
Influenzalike 30 (18) 5 (11) 6 (23) 18 (21)
Others 16 (10) 2 (4) 7 (27) 6 (7)
Only motor symptoms, no. (%) 101 (39) 31 (54) 11 (28) 57 (37) 0.056 0.35
Mechanical ventilation, no. (%) 87 (33) 23 (40) 15 (38) 43 (27) 0.20 0.49
Antibodies to gangliosides, no. (%)
GM1 30 (13) 24 (44) 0 5 (4) <0.0001 0.59
GM2 15 (6) 0 15 (47) 0 1.0 <0.0001

*CMV, cytomegalovirus; SD, standard deviation, IQR, interquartile range; GI, gastrointestinal illness; URTI, upper respiratory tract infection; LRTI, lower respiratory tract infection.
†Adjusted for unknown agent versus C. jejuni.
‡Adjusted for unknown agent versus CMV.

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