Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

Volume 12, Number 6—June 2006

Dispatch

Class 1 Integrons in Resistant Escherichia coli and Klebsiella spp., US Hospitals

Aarati N. Rao*1, Miriam Barlow*2, Leigh Ann Clark†, John R. Boring*, Fred C. Tenover†, and John E. McGowan*Comments to Author 
Author affiliations: *Emory University, Atlanta, Georgia, USA; †Centers for Disease Control and Prevention, Atlanta, Georgia, USA

Main Article

Table 1

Crude association between nonsusceptibility to various antimicrobial drugs and positive test result for class 1 integron in Escherichia coli and Klebsiella spp. (Klebsiella pneumoniae and K. oxytoca)

Class/agent E. coli (n = 209), OR (95% CI)* Klebsiella spp. (n = 111), OR (95% CI)*
Aminoglycosides
Amikacin 3.15 (0.32–30.79) 4.0 (0.86–18.51)
Gentamicin 5.04 (2.69–9.47) 4.49 (1.80–11.22)
Tobramycin 5.55 (3.01–10.23) 5.0 (2.0–12.52)
Fluoroquinolone
Ciprofloxacin 3.00 (1.40–6.42) 1.33 (0.59–3.04)
3rd-generation cephalosporin
Cefotaxime 1.14 (0.63–2.07) 2.26 (0.99–5.19)
Cefpodoxime 1.02 (0.59–1.75) 2.61 (1.05–6.52)
Ceftazidime 1.30 (0.73–2.31) 2.54 (1.10–5.88)
4th-generation cephalosporin
Cefepime 0.35 (0.11–1.13) 1.87 (0.57–6.10)
Monobactam
Aztreonam 1.58 (0.87–2.89) 1.10 (0.48–2.53)
β-Lactamase inhibitor
Piperacillin-tazobactam 1.40 (0.75–2.62) 1.82 (0.80–4.14)
Others
Chloramphenicol 2.33 (1.30–4.17) 2.29 (0.97–5.42)
Minocycline 1.57 (0.90–2.76) 1.20 (0.53–2.71)
Trimethoprim-sulfamethoxazole 12.24 (6.28–23.86) 3.68 (1.57–8.62)

*OR, odds ratio; CI, confidence interval. Variables with p values £0.05, in boldface, are considered significant.

Main Article

1Current affiliation: Midwestern University, Glendale, Arizona, USA

2Current affiliation: University of California at Merced, Merced, California, USA

TOP