Figure 3. Comparison of the predicted VP0-VP3 capsid protein region of Canadian isolates with that of Harris (human parechovirus [HPeV]-1), Williamson and Connecticut (HPeV-2), and A308-99 (HPeV-3) strains. The aligned region contains 284 amino acids. corresponding to residues 244 to 521 in the Harris polyprotein sequence (accession no. S45208). The VP3 N-terminal extension, which is specific to parechoviruses (21), is shaded. The cleavage site between VP0 and VP3 is underlined. Asterisks denote conserved residues. Boldface indicates HPeV reference strains.