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Volume 12, Number 6—June 2006

Research

Genetic Divergence of Toxoplasma gondii Strains Associated with Ocular Toxoplasmosis, Brazil

Asis Khan*, Catherine Jordan*, Cristina Muccioli†, Adriana L. Vallochi‡, Luiz V. Rizzo‡, Rubens Belfort†, Ricardo W.A. Vitor§, Claudio Silveira¶, and L. David Sibley*Comments to Author 
Author affiliations: *Washington University School of Medicine, St. Louis, Missouri, USA; †Paulista School of Medicine, São Paulo, Brazil; ‡University of São Paulo, São Paulo, Brazil; §Federal University of Minas Gerais, Belo Horizonte, Brazil; ¶Clinica Silveira, Erechim, Brazil

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Table

Genotypes of Toxoplasma gondii in human ocular toxoplasmosis samples from Brazil*

Strain name Type of sample Source Locus
5´-SAG2† 3´-SAG2‡ BTUB§ SAG3 GRA6 Genotype Reference¶ Location
ENT C# Human 1** 1 1,1 1 1 I ENT F
RH C Human 1 1 1,1 1 1 I RH USA-OH
GT1 C Goat 1 1 1,1 1 1 I GT1 USA-MD
VEL C Human 1 1 1,1 1 1 I VEL USA-CA
Me49 C Sheep 1 2 2,2 2 2 II Me49 USA-CA
DEG C Human 1 2 2,2 2 2 II DEG F
PIH C Human 1 2 2,2 2 2 II PIH USA-CA
CTG C Cat 2 1 2,1 3 3 III CTG USA-NIH
STRL C Human 2 1 2,1 3 3 III STRL USA-CA
VEG C Human 2 1 2,1 3 3 III VEG USA-CA
CAST C Human 1 1 1,1 1 1 I CAST USA-CA
COUG C Cougar 1 2 2,2 3 2 I/II/III COUG CAN-BC
MAS C Human 1 1 2,1 3 3 I/III MAS F
PBR C Dog 1 1 1,1 3 3 I/III MG1 SP
D3 C Dog 1 1 2,1 3 3 I/III MG2 MG
CH1 C Chicken 2 1 2,1 3 3 III MG3 MG
CH2 C Chicken 2 1 2,1 3 3 III MG4 MG
EFP C Human 1 1 2,1 3 3 I/III MG5 MG
SAF C Human 1 1 2,1 3 3 I/III MG6 MG
6T A†† Porcine 1 1 2,1 3 3 I/III P1 EC
7T A Porcine 1 1 2,1 3 3 I/III P2 EC
8T A Porcine 1 1 2,1 3 2 I/II/III P3 EC
9T A Porcine 1 1 2,1 3 3 I/III P4 EC
2147 Cl‡‡ Recurrent ocular 1 1 1,1 2 1 I/II ER1 ER
2324 Cl Acute ocular 1 1 1,1 2 1 I/II ER2 ER
2296 Cl Acute ocular 1 1 1,1 2 1 I/II ER3 ER
2323 Cl Acute ocular 1 1 1,1 2 1 I/II ER4 EC
2434 Cl Recurrent ocular 1 1 1,1 2 1 I/II ER5 ER
2325 Cl Acute ocular 1 1 1,1 3 1 I/III ER6 ER
2566 Cl Recurrent ocular 1 2 1,1 3 –§§ I/II/III ER7 ER
2583 Cl Acute ocular 1 1 1,1 1 I ER8 ER
2612 Cl Recurrent ocular 1 1,1 2 I/II ER9 ER
2670 Cl Recurrent ocular 1 1,1 2 I/II ER10 EC
2728 Cl Acute ocular 1 1 1,1 1 I ER11 EC
2694 Cl Outbreak 1 2 1,1 3 I/II/III SV SV
2712 Cl Outbreak 1 1,1 2 I/II AG1 AG
2717 Cl Outbreak 1 1,1 1 I AG2 AG
2719 Cl Outbreak 1 1 1,1 2 1 I/II AG3 AG

*C, culture; A, animal; Cl, clinical; F, France; CA, California; NIH, National Institutes of Health; CAN-BC, British Columbia, Canada; SP, São Paulo; MG, Belo Horizonte, Minas Gerais; EC, Erechim City; ER, Erechim region; SV, Santa Vitttoria do Palmar; AG, Agronomica.
†Genotypes I and II are the same.
‡Genotypes I and III are the same.
§Alleles represent BsiEI and TaqI, respectively.
¶As referred in figures.
#Culture strains used as reference.
**Alleles defined by pattern in type I strain = 1, second allele = 2; allele 3 is defined by the presence of a second biallelic polymorphism.
††Meat tissue samples, primary source.
‡‡Human ocular toxoplasmosis.
§§Refers to negative amplification product.

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