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Volume 12, Number 7—July 2006

Dispatch

Smallpox during Pregnancy and Maternal Outcomes

Hiroshi Nishiura*†Comments to Author 
Author affiliation: *University of Tübingen, Tübingen, Germany; †Hiroshima University, Hiroshima, Japan

Main Article

Table A2

Miscarriage or premature birth among pregnant women with smallpox by clinical types of variola major, according to data from 19th- and early 20th-century outbreaks

Reference Hemorrhagic
Confluent
Discrete
VSE
L/C PL (95% CI) L/C PL (95% CI) L/C PL (95% CI) L/C PL (95% CI)
Meyer (1), 1868–1872 13/13 100.0 (NC) 14/26 53.8 (34.7–73.0) 4/37 10.8 (0.8–20.8)
Sangregorio (2), 1887 3/3 100.0 (NC) 17/22 77.3 (59.8–94.8) 10/40 25.0 (11.6–38.4) 1/7 14.3 (0.0–40.2)
Charpentier (4), 1898 13/13 100.0 (NC) 18/34 52.9 (36.2–69.7) 9/45 20.0 (8.3–31.7)
Queirel (5), 1906 8/8 100.0 (NC) 3/3 100.0 (NC) 0/8 0.0 (NC)

*Hemorrhagic, widespread hemorrhages in the skin and mucous membranes; confluent, confluent rash on the face and arms; discrete, areas of normal skin visible between pustules, even on the face; VSE, variola sine eruptione, fever without rash caused by variola virus, also known as varioloid (8,9); L/C, miscarriage or premature birth/cases; PL, proportion of miscarriage or premature birth; CI, confidence interval; NC, not calculable.

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