TY - JOUR AU - Bowen, Anna AU - Braden, Christopher T1 - Invasive Enterobacter sakazakii Disease in Infants T2 - Emerging Infectious Disease journal PY - 2006 VL - 12 IS - 8 SP - 1185 SN - 1080-6059 AB - Enterobacter sakazakii kills 40%–80% of infected infants and has been associated with powdered formula. We analyzed 46 cases of invasive infant E. sakazakii infection to define risk factors and guide prevention and treatment. Twelve infants had bacteremia, 33 had meningitis, and 1 had a urinary tract infection. Compared with infants with isolated bacteremia, infants with meningitis had greater birthweight (2,454 g vs. 850 g, p = 0.002) and gestational age (37 weeks vs. 27.8 weeks, p = 0.02), and infection developed at a younger age (6 days vs. 35 days, p<0.001). Among meningitis patients, 11 (33%) had seizures, 7 (21%) had brain abscess, and 14 (42%) died. Twenty-four (92%) of 26 infants with feeding patterns specified were fed powdered formula. Formula samples associated with 15 (68%) of 22 cases yielded E. sakazakii; in 13 cases, clinical and formula strains were indistinguishable. Further clarification of clinical risk factors and improved powdered formula safety is needed. KW - Enterobacter sakazakii KW - meningitis KW - infant KW - infant formula KW - research KW - United Kingdom KW - Denmark KW - United States KW - the Netherlands KW - Portugal KW - Iceland KW - Israel KW - Belgium KW - France DO - 10.3201/eid1208.051509 UR - https://wwwnc.cdc.gov/eid/article/12/8/05-1509_article ER - End of Reference