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Volume 12, Number 8—August 2006

Research

Antibody Response to Pneumocystis jirovecii

Kieran R. Daly*†, Laurence Huang‡, Alison Morris§, Judy Koch*†, Kristina Crothers‡¶, Linda Levin†, Shary Eiser‡, Supriya Satwah†, Patrizia Zucchi‡#, and Peter D. Walzer*†Comments to Author 
Author affiliations: *Veterans Affairs Medical Center, Cincinnati, Ohio, USA; †University of Cincinnati, Cincinnati, Ohio, USA; ‡University of California, San Francisco, California, USA; §University of Southern California, Los Angeles, California, USA; ¶Yale University School of Medicine, New Haven, Connecticut, USA; #University of Pavia, Pavia, Italy

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Table 1

Demographic characteristics and baseline clinical measurements of patients with Pneumocystis pneumonia (PCP) and controls*

Characteristic PCP (n = 80) Controls
(n = 41)
Demographic
Male (%) 86 76
Race (%)
Caucasian 55 39
African American 29 39
Other 16 22
Age at enrollment (y) 41 ± 8 42 ± 8
Clinical
CD4 count (cells/μL)†‡ 29 ± 3 73 ± 4
Plasma HIV RNA (copies/mL)†‡ 123,130 ± 5 15,582 ± 24
Albumin (g/L) 3.0 ± 0.5 3.1 ± 0.7
Prior PCP (%) 24 33
Pneumonia severity
pO2 (mm Hg) 65 ± 15.6 73 ± 29
Aa gradient (mm Hg) 44 ± 13 41 ± 15
LDH (U/L)†‡ 359 ± 2 257 ± 2
Mechanical ventilation (%) 7 7
Serum antibody levels
MsgA† 5.6 ± 4.8 3.7 ± 3.5
MsgB† 2.9 ± 1.3 1.9 ± 0.9
MsgC† 4.2 ± 4.3 4.3 ± 3.4

*Unless specified otherwise, values are mean ± standard deviation. pO2, oxygen pressure; Aa, alveolar-arterial; LDH, lactate dehydrogenase; Msg, major surface glycoprotein.
†Geometric mean ± geometric standard deviation.
‡Significant difference between patient groups for CD4+ count (p<0.01), plasma HIV RNA (p<0.001), LDH (p<0.001).

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