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Volume 12, Number 8—August 2006

Research

Carbapenem Resistance in Klebsiella pneumoniae Not Detected by Automated Susceptibility Testing

Fred C. Tenover*Comments to Author , Rajinder K. Kalsi†, Portia P. Williams‡, Roberta B. Carey*, Sheila Stocker*, David Lonsway*, J. Kamile Rasheed*, James W. Biddle*, John E. McGowan‡, and Bruce Hanna†
Author affiliations: *Centers for Disease Control and Prevention, Atlanta, Georgia, USA; †Bellevue Hospital, New York, New York, USA; ‡Rollins School of Public Heath, Emory University, Atlanta, Georgia, USA

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Table 1

Carbapenem susceptibility and strain typing results for isolates tested in the study*

Organism Imipenem broth microdilution MIC† (μg/mL) and CLSI interpretation Meropenem broth microdilution MIC (μg/mL) and CLSI interpretation PFGE profile Hospital identification no.
1 Klebsiella pneumoniae 8 I 16 R A 1
2 K. pneumoniae 16 R >16 R A 1
3 K. pneumoniae 16 R 16 R A 2
4 K. pneumoniae 8 I 8 I A 2
5 K. pneumoniae 16 R >16 R A 2
6 K. pneumoniae 16 R 16 R A 2
7 K. pneumoniae 16 R 16 R A 3
8 K. pneumoniae 32 R 16 R A 4
9 K. pneumoniae 16 R >16 R B 1
10 K. pneumoniae 16 R >16 R B 1
11 K. pneumoniae 16 R 16 R C 4
12 K. pneumoniae 16 R 16 R D 1
13 K. pneumoniae 16 R 16 R E 4
14 K. pneumoniae 16 R >16 R F 1
15 K. pneumoniae 16 R >16 R F1 4
K. pneumoniae
1534 (control) 16 R >16 R NA NA
Serratia marcescens
525 (control) >16 R >16 R NA NA

*CLSI, Clinical and Laboratory Standards Institute; PFGE, pulsed-field gel electrophoresis; NA, not applicable.†Interpretations of MIC results used CLSI criteria (18); I, intermediate; R, resistant.

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