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Volume 12, Number 8—August 2006

Research

Carbapenem Resistance in Klebsiella pneumoniae Not Detected by Automated Susceptibility Testing

Fred C. Tenover*Comments to Author , Rajinder K. Kalsi†, Portia P. Williams‡, Roberta B. Carey*, Sheila Stocker*, David Lonsway*, J. Kamile Rasheed*, James W. Biddle*, John E. McGowan‡, and Bruce Hanna†
Author affiliations: *Centers for Disease Control and Prevention, Atlanta, Georgia, USA; †Bellevue Hospital, New York, New York, USA; ‡Rollins School of Public Heath, Emory University, Atlanta, Georgia, USA

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Table 2

Summary of antimicrobial susceptibility testing results for 15 test isolates*

Method (software) Card/panel Imipenem results (n = 15)
Meropenem results (n = 15)
Resistant Intermediate Susceptible Resistant Intermediate Susceptible
Broth microdilution In-house frozen panel 13 2 0 14 1 0
Disk diffusion BDDS disks 3 11 1 10 5 0
MicroScan (LabPro1.51, Alert 1.50) Neg combo 32 7 7 1 13 1 1
Phoenix (4.05W/3.81A) NMIC/ ID-104 5 8 2 12 1 2
Sensititre AutoReader (3.0.8 SP2) GN2F 0 2 13 0 3 12
VITEK (R10.01) Superflex GNS 122 and 127 5 0 10 2 3 10
VITEK 2* (R04.01) GN07 4 6 5 4 4 5

*No meropenem interpretations were given by the Advanced Expert System for 2 organisms.

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