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Volume 12, Number 9—September 2006
Research

Genomic Signatures of Human versus Avian Influenza A Viruses

Guang-Wu Chen*1, Shih-Cheng Chang*1, Chee-Keng Mok*, Yu-Luan Lo*, Yu-Nong Kung*, Ji-Hung Huang*, Yun-Han Shih*, Ji-Yi Wang*, Chiayn Chiang*, Chi-Jene Chen*, and Shin-Ru Shih*Comments to Author 
Author affiliations: *Chang Gung University, Taoyuan, Taiwan, Republic of China

Main Article

Table 3

Twenty-one avian influenza A viral genomes isolated from humans and their mutations found at 12 host-associated positions within each strain*

Strain Subtype PB2
PB1-F2
PA
M2
NS2
Mutations
199 271 627 73 79 82 409 20 70
A/Hong Kong/156/1997 H5N1 S T E K R L N S S 2
A/Hong Kong/481/1997 H5N1 A T E K R L N S S 1
A/Hong Kong/482/1997 H5N1 S T E K R L N S S 2
A/Hong Kong/483/1997 H5N1 A T K K R L S S S 1
A/Hong Kong/485/1997 H5N1 A T K # # # S S S 1
A/Hong Kong/486/1997 H5N1 S T E K R L N S S 2
A/Hong Kong/532/1997 H5N1 A T E K R L N S S 1
A/Hong Kong/538/1997 H5N1 S T E K R L N S S 2
A/Hong Kong/542/1997 H5N1 A T E K R L N S S 1
A/Hong Kong/1997/1998 H5N1 S T E K R L S S S 1
A/Hong Kong/212/2003 H5N1 A T E R R L S S S 1
A/Hong Kong/213/2003 H5N1 A T E R R L S S S 1
A/Thailand/16/2004 H5N1 A T K K Q L S S S 2
A/Thailand/SP83/2004 H5N1 A T E K Q L S S S 1
A/Vietnam/1194/2004 H5N1 A T K K R L S S S 1
A/Vietnam/1203/2004 H5N1 A T K K R L S S S 1
A/Vietnam/3062/2004 H5N1 A T K K R L S S S 1
A/Netherlands/219/2003 H7N7 A T K K R S S N S 3
A/Guangzhou/333/1999 H9N2 A A E # # # S S G 2
A/Hong Kong/1073/1999 H9N2 A T E K R L S R S 0
A/Hong Kong/1074/1999 H9N2 A T E K R L S S S 0

*#indicates strains with PB1 RNA encoded into a truncated form of PB1-F2 of only 57 amino acids long. Boldface letters represent mutated (human-specific) residues; Roman (nonbold) letters are used for regular avian residue. Note that at position 20 of M2, A/Hong Kong/1073/99 had its residue changed from S to R, where R is still considered a mutation within avian species.

Main Article

1These authors contributed equally to this article.

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Page updated: November 18, 2011
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