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Volume 13, Number 1—January 2007

Research

Blood Transfusion and Spread of Variant Creutzfeldt-Jakob Disease

Klaus Dietz*Comments to Author , Günter Raddatz*, Jonathan Wallis†, Norbert Müller‡, Inga Zerr§, Hans-Peter Duerr*, Hans Lefèvre¶, Erhard Seifried#, and Johannes Löwer**
Author affiliations: *University of Tübingen, Tübingen, Germany; †Freeman Hospital, Newcastle upon Tyne, United Kingdom; ‡University Hospital Essen, Essen, Germany; §University of Göttingen, Göttingen, Germany; ¶DRK Blood Donor Service West, Hagen, Germany; #DRK Blood Donor Service Baden-Württemberg, Hessen, Frankfurt am Main, Germany; **Paul-Ehrlich-Institute, Langen, Germany;

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Figure 1

Figure 1 - A) States and transitions for the model of blood transfusion in the absence of an infection. B) Routes of infection. The arrows representing deaths out of all states are omitted. Paths of donor exclusion are plotted by dotted arrows. S00, nonrecipients who do not donate; S01, nonrecipients who donate; S02,nonrecipients who are excluded from donating; S100,recipients who do not donate; S101, recipients who become excluded from donating; S110, recipients who donate; S111, reci

Figure 1. A) States and transitions for the model of blood transfusion in the absence of an infection. B) Routes of infection. The arrows representing deaths out of all states are omitted. Paths of donor exclusion are plotted by dotted arrows. S00, nonrecipients who do not donate; S01, nonrecipients who donate; S02,nonrecipients who are excluded from donating; S100,recipients who do not donate; S101, recipients who become excluded from donating; S110, recipients who donate; S111, recipients who become excluded from donating; S12, recipients who are excluded from donating. Indices replaced by a dot (panel B) represent all other possible states (e.g., S0• represents S00, S01, or S02).

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