TY - JOUR AU - Cohen, Cheryl AU - White, Joanne AU - Savage, Emma AU - Glynn, Judith AU - Choi, Yoon AU - Andrews, Nick AU - Brown, David AU - Ramsay, Mary T1 - Vaccine Effectiveness Estimates, 2004–2005 Mumps Outbreak, England T2 - Emerging Infectious Disease journal PY - 2007 VL - 13 IS - 1 SP - 12 SN - 1080-6059 AB - The United Kingdom and United States have recently experienced large outbreaks of mumps, which raises concerns about vaccine effectiveness. The effectiveness of the mumps component of the measles, mumps, rubella (MMR) vaccine was estimated using the screening method. In England from January 2004 through March 2005, 312 cases of mumps were reported in children eligible to have received 2 doses of MMR vaccine. Of these children, 52 (16.7%) had received 1 dose of MMR vaccine, and 97 (31.1%) had received 2 doses. Vaccine effectiveness was 88% (95% confidence interval [CI] 83%–91%) for 1 dose and 95% (95% CI 93%–96%) for 2 doses. The effectiveness of 1 dose declined from 96% (95% CI 81%–99%) in 2-year-olds to 66% (95% CI 30%–83%) in 11- to 12-year-olds, and the effectiveness of 2 doses declined from 99% (95% CI 97%–99.5%) in 5- to 6-year-olds to 86% (95% CI 74%–93%) in 11- to 12-year-olds (p<0.001 for 1 or 2 doses). Waning immunity may contribute to mumps outbreaks in older vaccinated populations. KW - Measles KW - mumps KW - rubella vaccine KW - vaccine effectiveness KW - outbreak KW - England KW - research DO - 10.3201/eid1301.060649 UR - https://wwwnc.cdc.gov/eid/article/13/1/06-0649_article ER - End of Reference