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Volume 13, Number 1—January 2007

Dispatch

Ophthalmic Surgery in Prion Diseases

Tsuyoshi Hamaguchi*1, Moeko Noguchi-Shinohara*, Yosikazu Nakamura†2, Takeshi Sato‡2, Tetsuyuki Kitamoto§2, Hidehiro Mizusawa¶2, and Masahito Yamada*2Comments to Author 

Author affiliations: *Kanazawa University Graduate School of Medical S cience, Kanazawa, Japan; †Jichi Medical University, Shimotsuke, Japan; ‡National Center for Neurology and Psychiatry, Ichikawa, Japan; §Tohoku University Graduate School of Medicine, Sendai, Japan; ¶Tokyo Medical and Dental University, Tokyo, Japan;

Main Article

Table 2

Clinical symptoms of sCJD within 2 mo after disease onset*

Characteristic Ophthalmic surgery
Total p value
No, n = 458 Yes, n = 10
Female/male 263/195 6/4 269/199 0.57
Age at onset, y; mean ± SD 66.8 ± 9.9 68.3 ± 9.1 66.8 ± 9.9 0.74
Disease duration,† mean ± SD 4.2 ± 4.8 9.1 ± 6.0 4.3 ± 4.9 0.0004
Clinical symptoms (%)
  Dementia (+)/visual impairment (+) 153 (34.2) 4 (40.0) 157 (34.3)
  Dementia (+)/visual impairment (–) 239 (53.3) 3 (30.0) 242 (52.8) 0.0004
  Dementia (–)/visual impairment (+) 16 (3.6) 3 (30.0) 19 (4.1)
  Dementia (–)/visual impairment (–) 40 (8.9) 0 40 (8.7)

*sCJD, sporadic Creutzfeldt-Jakob disease; SD, standard deviation; +, with; –, without.
†Disease duration, the duration from onset to akinetic mutism or death if patients never displayed akinetic mutism.

Main Article

1Current affiliation: Ishikawa Prefecture Central Hospital, Kanazawa, Japan

2Member, Creutzfeldt-Jakob Disease Surveillance Committee, Japan

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