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Volume 13, Number 11—November 2007

Research

Human Salmonella and Concurrent Decreased Susceptibility to Quinolones and Extended-Spectrum Cephalosporins

Jean M. Whichard*Comments to Author , Kathryn Gay*1, Jennifer E. Stevenson*2, Kevin J. Joyce*, Kara L. Cooper*, Michael Omondi*, Felicita Medalla*, George A. Jacoby†, and Timothy J. Barrett*
Author affiliations: *Centers for Disease Control and Prevention, Atlanta, Georgia, USA; †Lahey Clinic, Burlington, Massachusetts, USA;

Main Article

Table 3

Susceptibility results for NARMS non-Typhi Salmonella isolates with decreased susceptibility to quinolones and extended-spectrum cephalosporins, United States, 1996–2004*

Isolate Resistance
NAL CIP XNL CRO TAZ TAZ/ CLAV FOT FOT/
CLAV Other†
AM18280 >32 0.25 >8 16 32 16/4 16 8/4 AMP, AMC, CHL, FOX, KAN, STR, SUL, SXT, TET
AM09124 >32 0.5 2 <0.25 0.5 0.25/4 0.25 0.12/4 ND
AM15266 >32 0.5 2 <0.25 0.5 0.25/4 0.25 0.12/4 (CHL)
AM12389 >32 0.5 2 <0.25 0.25 0.25/4 0.1 0.12/4 (CHL), SUL, SXT, TET
AM15010 16 0.25 8 8 64 0.5/4 4 0.25/4 AMP, (CHL), SUL, SXT
AM03005 16 0.25 2 0.5 0.25 0.12/4 0.12 ≤0.06/4 AMP, AMC, CHL, FOX, (GEN), KAN, STR, SUL, SXT
AM15201 >32 0.12 >8 8 16 16/4 16 8/4 AMP, AMC, CHL, FOX, STR, SUL, TET
AM21465 >32 0.12 >8 16 16 16/4 8 8/4 AMP, AMC, CHL, FOX, STR, SUL, TET
AM20428 >32 0.5 2 <0.25 0.5 0.5/4 0.5 0.12/4 (CHL), (FOX)
AM06960 >32 >4 8 8 0.5 0.25/4 1 0.12/4 AMP, AMC, (CHL), GEN, KAN, STR, SUL, SXT
AM08081 >32 >4 4 0.5 0.5 0.25/4 1 0.12/4 AMP, AMC, CHL, FOX, (GEN), KAN, STR, SUL, SXT
AM08208 >32 >4 2 <0.25 0.5 0.25/4 0.5 0.25/4 AMP, (AMC) CHL, GEN, KAN, STR, SUL, SXT, TET
AM09864 >32 >4 8 8 64 0.25/4 8 0.25/4 AMP, (CHL), (FOX), GEN, KAN
AM11007 >32 >4 4 0.5 1 0.5/4 1 0.5/4 AMP, AMC, CHL, (FOX), KAN, SUL
AM14058 >32 >4 >8 >64 64 64/4 128 >64/4 (AMI), AMP, AMC, CHL, FOX, KAN, SUL
AM16094 >32 >4 4 <0.25 0.5 0.25/4 1 0.25/4 AMP, (AMC), CHL, (FOX), (GEN), KAN, SUL, SXT
AM18622 >32 >4 8 1 2 0.5/4 4 0.5/4 AMP, AMC, CHL, KAN, STR, SUL, SXT
AM19422 >32 >4 4 <0.25 0.5 0.5/4 2 0.25/4 AMP, AMC, (GEN), KAN, STR, SUL, SXT
AM20227 >32 >4 2 <0.25 1 2/4 1 0.5/4 AMP, AMC, (CHL), (FOX), GEN, KAN, STR, SUL, SXT
AM20256 >32 >4 4 <0.25 0.5 0.5/4 1 0.25/4 AMP, (AMC), (CHL), (GEN), KAN, SUL, SXT
AM02544 256 0.25 >16 64 128 0.5/4 32 0.12/4 AMP, (AMC), KAN, STR, SUL, TET
AM08739 >32 0.25 >8 32 16 16/4 16 8/4 AMP, AMC, CHL, FOX, GEN, KAN, STR, SUL, TET
AM11682 >32 0.25 >8 16 16 8/4 16 8/4 AMP, AMC, FOX
AM14364 >32 0.25 >8 32 32 16/4 32 16/4 AMP, AMC, CHL, FOX, GEN, KAN, STR, SUL, TET
AM14807 >32 0.25 >8 16 32 16/4 16 32/4 AMP, AMC, CHL, FOX, STR, SUL, TET
AM20205 >32 0.25 2 <0.25 0.5 0.5/4 0.25 0.25/4 AMP, KAN, STR, SUL, TET
AM19537 >32 0.12 >8 16 16 16/4 8 8/4 AMP, AMC, CHL, FOX, (GEN), (KAN), STR, SUL TET

*NARMS, National Antimicrobial Resistance Monitoring System; NAL, nalidixic acid; CIP, ciprofloxacin; XNL, ceftiofur; CRO, ceftriaxone; TAZ, ceftazidime; TAZ/CLAV, ceftazidime/clavulanate; FOT, cefotaxime, FOT/CLAV, cefotaxime/clavulanate; AMP, ampicillin; AMC, amoxicillin/clavulanate; CHL, chloramphenicol; FOX, cefoxitin; KAN, kanamycin; STR, streptomycin; SUL, sulfamethoxazole or sulfisoxazole; SXT, trimethoprim/sulfamethoxazole; TET, tetracycline; AMI, amikacin; GEN, gentamicin.
†Drugs in parentheses had intermediate results.

Main Article

1Current affiliation: Banfield, The Pet Hospital, Philadelphia, Pennsylvania, USA

2Current affiliation: Washington State University, Pullman, Washington, USA

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