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Volume 13, Number 11—November 2007

Dispatch

Viral Load as Predictor of Crimean-Congo Hemorrhagic Fever Outcome

Darja Duh*, Ana Saksida*, Miroslav Petrovec*, Salih Ahmeti†, Iusuf Dedushaj‡, Marcus Panning§, Christian Drosten§, and Tatjana Avšič-Županc*Comments to Author 
Author affiliations: *Institute of Microbiology and Immunology, Ljubljana, Slovenia; †Clinic of Infectious Diseases, Pristina, Kosovo; ‡National Institute of Public Health, Pristina, Kosovo; §Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany;

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Table

Detection of CCHF viral load by real-time RT-PCR in serum of patients with acute CCHF, Kosovo*

Patient no. Disease severity Day of illness IgM titer IgG titer Viral load (copies/mL)
1 Fatal 2 Neg Neg 6.5100 × 108
2 Fatal 3 Neg Neg 2.5040 × 109
3 Fatal 4 Neg Neg 2.7400 × 109
4 Fatal 9 Neg Neg 3.3840 × 109
5 Fatal 4 1,600 Neg 1.0160 × 108
6 Fatal 6 3,200 Neg 1.3450 × 1010
7 Fatal 7 400 Neg 1.8675 × 109
8 Fatal 7 800 Neg 3.4800 × 109
9 Fatal 7 800 Neg 1.2920 × 109
10 Severe 8 >6,400 Neg 1.6050 × 106
18 >6,400 400 1.1500 × 105
11 Severe 9 Neg Neg 2.3250 × 107
24 >6,400 >6,400 Neg
12 Severe 4 800 Neg 3.3900 × 106
16 6,400 3,200 Neg
13 Severe 2 Neg Neg 1.0430 × 109
9 >6,400 400 3.1200 × 103
42 > 6,400 3,200 Neg
14 Severe 8 Neg Neg 8.1000 × 106
14 6,400 Neg 2.0100 × 103
15 Severe 3 Neg Neg 3.8100 × 107
14 6,400 200 Neg
16 Severe 3 >1,600 Neg 2.5235 × 106
6 >800 >800 2.2350 × 104
17 Severe 4 Neg Neg 3.3600 × 107
10 >6,400 100 3.8100 × 104
18 Severe 2 Neg Neg 7.8500 × 107
9 6,400 400 3.2000 × 103
23 >6,400 >6,400 Neg
19 Moderate 12 >6,400 Neg 5.7525 × 104
17 >6,400 800 Neg
20 Moderate 9 >6,400 1,600 1.9600 × 103
11 >6,400 3,200 Neg
21 Moderate 12 >6,400 800 1.9191 × 105
13 >6,400 3,200 1.0240 × 104
32 >6,400 >6,400 Neg
22 Moderate 10 >6,400 Neg 4.6400 × 104
19 >6,400 >6,400 1.2000 × 103
26 >6,400 >6,400 Neg
23 Moderate 9 6,400 6,400 7.6800 × 103
20 >6,400 >6,400 7.5000 × 102
24 Moderate 7 400 Neg 7.4400 × 105
18 >6,400 6,400 Neg

*CCHF, Crimean-Congo hemorrhagic fever: RT-PCR, reverse transcription–PCR; Ig, immunoglobulin; neg, negative result.

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