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Volume 13, Number 11—November 2007

Research

Genetic Diversity among Clonal Lineages within Escherichia coli O157:H7 Stepwise Evolutionary Model

Peter C.H. Feng*Comments to Author , Steven R. Monday*, David W. Lacher†, Lesley Allison‡, Anja Siitonen§, Christine Keys*, Marjut Eklund§, Hideki Nagano¶, Helge Karch#, James Keen**, and Thomas S. Whittam†
Author affiliations: *Food and Drug Administration, College Park, Maryland, USA; †Michigan State University, East Lansing, Michigan, USA; ‡Western General Hospital, Edinburgh, Scotland; §National Public Health Institute, Helsinki, Finland; ¶Hokkaido Institute of Public Health, Hokkaido, Japan; #University of Munster, Munster, Germany; **US Department of Agriculture, Clay Center, Nebraska, USA;

Main Article

Table 1

Characteristics of Escherichia coli O157 strains*

Source No. SOR GUD Τe O157 H7 fliC stx1 stx2 γeae ehxA +93 +776 +686 BAP ΔflhC
G5101 + R + + + + + + + + + +
USA 1 + R + + ND + + + + + + + NA
2 + R + + ND + + + + + + NA
Japan 22 + R + + ND + + + + + + + NA
498/89 + + S + + + + + + NA +
Germany 5 + + S + + + + + + NA +
2 + + S + + + + + NA +
Scotland 4 + + S + + + + + + NA +
1 + + S + + + + + NA +
Finland 6 + + S + + + + + + NA +
2 + + S + + + + + NA +
LSU-61 + + R + + + + + + NA +

*SOR, sorbitol fermentation; GUD, β-glucuronidase activity; Te, tellurite resistant (R) or sensitive (S); O157, antigen; H7, antigen; fliC, H7 flagella gene; stx1, shiga toxin 1 gene; stx2, shiga toxin 2 gene; γeae, γ-intimin; ehxA, enterohemolysin gene; +93, uidA single nucleotide polymorphisms (SNP); +776, uidA SNP; +686, uidA G-G insertion; BAP, enterohemolysin activity on blood agar plates; ΔflhC, 12-bp deletion; ND, not done; NA, not applicable.

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