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Volume 13, Number 11—November 2007

Research

Epidemiologic and Virologic Investigation of Hand, Foot, and Mouth Disease, Southern Vietnam, 2005

Phan Van Tu*, Nguyen Thi Thanh Thao*, David Perera†, Khanh Huu Truong‡, Nguyen Thi Kim Tien*, Tang Chi Thuong‡, Ooi Mong How§, Mary Jane Cardosa†, and Peter Charles McMinn¶Comments to Author 
Author affiliations: *Pasteur Institute, Ho Chi Minh City, Vietnam; †Universiti Malaysia Sarawak, Kota Samarahan, Sarawak, Malaysia; ‡Children’s Hospital No. 1, Ho Chi Minh City, Vietnam; §Sibu General Hospital, Sibu, Sarawak, Malaysia; ¶University of Sydney, Sydney, New South Wales, Australia;

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Figure 5

Dendrogram constructed by using the neighbor-joining method (25) showing the genetic relationships between 23 human enterovirus 71 (HEV71) strains isolated in southern Vietnam during 2005 (underlined), based on the alignment of complete VP1 gene sequences. Branch lengths are proportional to the number of nucleotide differences. The bootstrap values in 1,000 pseudoreplicates for major lineages within the tree are shown as percentages. The marker denotes a measurement of relative phylogenetic distance. Strain names indicate a unique numerical abbreviation of country and year of isolation. Asterisks (*) denote HEV71 isolates obtained from fatal cases. The prototype coxsackievirus 16 (CVA16)–G10 strain (28) was used as an outgroup. The dendrogram shows genogroups A, B, and C as identified by Brown et al. (24). Details of the strains used to prepare the dendrogram are shown in Table 1.

Figure 5. Dendrogram constructed by using the neighbor-joining method (25) showing the genetic relationships between 23 human enterovirus 71 (HEV71) strains isolated in southern Vietnam during 2005 (underlined), based on the alignment of complete VP1 gene sequences. Branch lengths are proportional to the number of nucleotide differences. The bootstrap values in 1,000 pseudoreplicates for major lineages within the tree are shown as percentages. The marker denotes a measurement of relative phylogenetic distance. Strain names indicate a unique numerical abbreviation of country and year of isolation. Asterisks (*) denote HEV71 isolates obtained from fatal cases. The prototype coxsackievirus 16 (CVA16)–G10 strain (28) was used as an outgroup. The dendrogram shows genogroups A, B, and C as identified by Brown et al. (24). Details of the strains used to prepare the dendrogram are shown in Table 1.

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