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Volume 13, Number 11—November 2007

Synopsis

Literature Review and Case Histories of Histoplasma capsulatum var. duboisii Infections in HIV-infected Patients

Pierre Loulergue*†, Frédéric Bastides‡, Véronique Baudouin§, Jacques Chandenier‡, Patricia Mariani-Kurkdjian§, Bertrand Dupont*†, Jean-Paul Viard*†, Françoise Dromer¶, and Olivier Lortholary†¶Comments to Author 
Author affiliations: *University Paris V, Paris, France; †Hôpital Necker-Enfants Malades, Paris, France; ‡Centre Hospitalier Universitaire Bretonneau, Tours, France; §Hôpital Robert Debré, Paris, France; ¶Institut Pasteur, Paris, France;

Main Article

Table 2

Comparison of clinical and microbiologic findings of HIV-infected and immunocompetent patients with histoplasmosis due to variety duboisii*†

Characteristic HIV positive (n = 17) HIV negative (n = 20)
Age, y (range) 35 (2–65) 34 (8–62)
Sex (M:F)
12:5
19:1
Visceral localizations
Lymph nodes 53 65
Skin 59 40
Bones 18 25
Lungs 0† 35†
Gastrointestinal 12 5
Disseminated
85†
55†
Clinical manifestations
Fever 58† 15†
Weight loss, asthenia, anorexia 54 30
Respiratory symptoms 0 20
Hepatosplenomegaly
12
15
Diagnosis sites
Lymph nodes 24 45
Skin 48 35
Bone marrow 18 0
Bone 12 5
Gastrointestinal 6 5
Pus 6 25
Lung
0†
25†
Mycologic diagnosis
Direct examination 100 40
Culture 64 65
Blood culture
12
0
Treatment
Amphotericin B 66 80
Ketoconazole 12 35
Itraconazole 64 20
Fluconazole
12
0
Outcome
Relapse 12 40
Death 24 5

*Except where indicated, all values are percentages. HIV-negative patients are from Dupont et al. (13).
†p<0.05.

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