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Volume 13, Number 12—December 2007

Dispatch

Human and Animal Infections with Mycobacterium microti, Scotland

Francis Xavier Emmanuel*, Amie-Louise Seagar*Comments to Author , Christine Doig*, Alan Rayner*, Pauline Claxton*, and Ian Laurenson*
Author affiliations: *Scottish Mycobacteria Reference Laboratory, Edinburgh, Scotland, United Kingdom;

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Table 2

Laboratory features of Mycobacterium microti isolates from Scotland*†

Source Specimen Direct AFB Growth on primary isolation
Drug susceptibility Genotype
Solid culture
Liquid culture
IUT PYR MB/MGIT
Human 1 Sputum Positive + Failed to grow in liquid cultures Llama type SIT641
(spacers 4–7, 23,24, 37, and 38)
Human 2 Sputum Positive
(many) + Failed to grow in liquid cultures Llama type SIT641
Human 3 Sputum Positive
(many) + Susceptible to R, I, E; resistant to P Llama type SIT641
Human 4 Sputum Positive
(few) + + Failed to grow in liquid culture Llama type
(spacers 4–7 and 23,24 only)
Cat 1 Tissue/lymph node Negative + Failed to grow in liquid cultures Llama type SIT641
Badger Tissue/lung Strongly positive + + ± Inadequate growth Vole type SIT 539
(spacers 37 and 38)
Cat 2 Tissue/lymph node Negative + Susceptible to R,I,E,P
(grew on liquid subculture) Vole type SIT539
Llama Tissue/lung Positive + + Failed to grow in liquid culture Llama type SIT641
Ferret Tissue Positive ± ± ± Susceptible to R,I,E,P Not tested

*AFB, acid-fast bacilli; IUT, International Union Against Tuberculosis formulation of solid egg medium; PYR, IUT medium with pyruvate supplementation; MB, MBBact, Biomerieux, Basingstoke, United Kingdom; MGIT, Mycobacteria Growth Indicator Tube, Becton Dickinson; R,I,E,P, rifampin, isoniazid, ethambutol, pyrazinamide; SIT, Spoligo-International-Type.
†SIT numbers: designations in International spoligotyping database (Spol DB4) (14).

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