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Volume 13, Number 12—December 2007

Research

Phenotypic Similarity of Transmissible Mink Encephalopathy in Cattle and L-type Bovine Spongiform Encephalopathy in a Mouse Model

Thierry G.M. Baron*Comments to Author , Anna Bencsik*, Anne-Gaëlle Biacabe*, Eric Morignat*, and Richard A. Bessen†
Author affiliations: *Agence Française de Sécurité Sanitaire des Aliments–Lyon, Lyon, France; †Montana State University, Bozeman, Montana, USA;

Main Article

Table

TSE sources transmitted to TgOvPrP4 mice*

TSE sources Nature First passage
Second passage
Survival periods (mean ± SD dpi) No. PrPd positive mice/total† Survival periods (mean ± SD dpi) No. PrPd positive mice/total†
Experimental isolates
TME TME 436 ± 77 9/11 234 ± 27 9/9
SB1
Ovine BSE
296 ± 46
19/19

365 ± 36
11/12
Natural isolates
02-2528 L-type BSE 627 ± 74 9/10 202 ± 26 9/9
03-2095 H-type BSE 692 ± 129 0/8 ND ND
01-2281 Typical BSE 421 ± 48 10/10 354 ± 48 10/10

*TSE, transmissible spongiform encephalopathy; dpi, days postinoculation; PrPd, disease-associated prion protein; TME, transmissible mink encephalopathy; BSE, bovine spongiform encephalopathy; ND, not done.
†Results obtained by Western blot or by immunohistochemical test.

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