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Volume 13, Number 2—February 2007

Research

Invasive Group B Streptococcal Infection in Infants, Malawi

Katherine J. Gray*Comments to Author , Sally L. Bennett†, Neil French*, Amos J. Phiri*, and Stephen M. Graham*†
Author affiliations: *Malawi-Liverpool–Wellcome Trust Programme of Clinical Tropical Research, Blantyre, Malawi; †College of Medicine, Blantyre, Malawi;

Main Article

Table

Characteristics of 57 case-patients with group B streptococcal infection overall and in relation to capsular serotype

Serotype
Clinical featuresTotal (%)Ia
(n = 12)Ib
(n = 3)Ll
(n = 4)Lll
(n = 32)V
(n = 1)Unknown
(n = 5)
Early onset disease*297231412
Male sex†15 (52)‡622401
Meningitis5 (17)111200
Probable meningitis4 (14)100300
Sepsis15 (52)511800
Pneumonia0 (0)
Undefined5 (17)
0
0
1
1
1
2
Low birthweight§¶5 (17)210200
Premature#**3 (10)
2
0
0
1
0
0
Late onset disease††285111803
Male sex‡‡13 (46)211900
Meningitis11 (39)200801
Probable meningitis1 (4)000100
Sepsis10 (36)110800
Pneumonia3 (11)101100
Undefined3 (11)
1
0
0
0
0
2
Low birthweight§§5 (18)201101
Premature¶¶4 (14)
2
0
1
1
0
0
Case fatality‡
Early onset disease11 (38)300800
Late onset disease8 (29)300401
Unknown3 (5)
0
0
1
1
0
1
Sensitivity, %
Penicillin100100100100100100100
Erythromycin79901006778078
Tetracycline417000011
Ceftriaxone100100100100100100100
Chloramphenicol819010010078077

*Illness onset between birth and day 6.
†Missing information on 3 cases.
‡Expressed as a proportion of total early or late onset cases.
§Weight at birth <2.5 kg.
¶Missing information on 2 cases.
#Delivery before 37 weeks of gestation.
**Missing information on 6 cases.
††Illness onset ≥7 d after delivery.
‡‡Missing information on 2 cases.
§§Missing information on 4 cases.
¶¶Missing information on 6 cases.

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