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Volume 13, Number 3—March 2007

Research

Matrix Protein 2 Vaccination and Protection against Influenza Viruses, Including Subtype H5N1

Stephen Mark Tompkins*1Comments to Author , Zi-Shan Zhao*, Chia-Yun Lo*, Julia A. Misplon*, Teresa Liu*, Zhiping Ye*, Robert J. Hogan†, Zhengqi Wu*, Kimberly A. Benton*, Terrence M. Tumpey‡, and Suzanne L. Epstein*
Author affiliations: *Food and Drug Administration, Bethesda, Maryland, USA; †University of Georgia, Athens, Georgia, USA; ‡Centers for Disease Control and Prevention, Atlanta, Georgia, USA;

Main Article

Table

Sequences of matrix protein 2 (M2) ectodomains

StrainAbbreviationSubtypeM2e Sequence*†
Consensus
M2e-con

MSLLTEVETPIRNEWGCRCNDSSD
A/PR/8
M2e-PR8
H1N1
MSLLTEVETPIRNEWGCRCNGSSD
A/FM/1/47-MA
M2e-FM
H1N1
MSLLTEVETPTKNEWECRCNDSSD
A/HK/156/97
M2e-H5(HK)
H5N1
MSLLTEVETLTRNGWGCRCSDSSD
A/Thailand/SP-83/04M2e-H5(SP-83)H5N1MSLLTEVETPTRNEWECRCSDSSD

*Variations from the M2e consensus sequence are in boldface.
†Virus sequences available at www.ncbi.nlm.nih.gov/genomes/FLU and www.flu.lanl.gov
‡Consensus sequence derived from human influenza viruses of H1, H2, and H3 subtypes (9,13).

Main Article

1Current affiliation: University of Georgia, Athens, Georgia, USA

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