Figure 1. Geographic distribution of hospitals where 16S rRNA methylase gene–positive strains were isolated. Of 16 hospitals, 8 were located in the Kanto area (Gunma, Tokyo, Shizuoka, and Nagano), 3 in the Chubu area (Aichi and Gifu), 4 in the Kinki area (Osaka, Nara, and Hyogo), and 1 in the Kyushu area (Miyazaki). This distribution suggests a sparse but diffuse spread of 16S rRNA methylase–producing, gram-negative pathogenic microbes in Japan. Bacterial species and type of 16S rRNA methylase identified in each hospital are shown in Table 3.