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Volume 13, Number 4—April 2007

Dispatch

16S rRNA Methylase–producing, Gram-Negative Pathogens, Japan

Kunikazu Yamane*, Jun-ichi Wachino*, Satowa Suzuki*, Naohiro Shibata*, Haru Kato*, Keigo Shibayama*, Kouji Kimura*, Kumiko Kai*, Satoshi Ishikawa*, Yoshiyuki Ozawa*, Toshifumi Konda*, and Yoshichika Arakawa*Comments to Author 
Author affiliations: *National Institute of Infectious Diseases, Tokyo, Japan;

Main Article

Table 3

MICs of antimicrobial agents for arbekacin-resistant strains*†‡

Strain no. MIC (mg/L)
ABK AMK TOB ISP GEN SM NEO CTX CAZ IPM CIP
40 >1,024 >1,024 >1,024 >1,024 >1,024 8 >1,024 <0.06 0.125 0.125 64
64 >1,024 >1,024 >1,024 >1,024 >1,024 8 >1,024 <0.06 0.5 0.125 64
101 >1,024 >1,024 >1,024 >1,024 >1,024 32 >1,024 8 2 0.5 32
103 >1,024 >1,024 >1,024 >1,024 >1,024 32 16 64 2 0.5 <0.06
109 >1,024 >1,024 >1,024 >1,024 >1,024 8 16 64 16 0.5 <0.06
113 >1,024 >1,024 >1,024 >1,024 >1,024 128 512 16 2 16 0.125
127 >1,024 >1,024 >1,024 >1,024 >1,024 128 128 16 2 16 <0.06
157 >1,024 >1,024 >1,024 >1,024 >1,024 32 32 64 4 2 0.5
158 >1,024 >1,024 >1,024 >1,024 >1,024 128 512 32 8 16 0.125
231 >1,024 >1,024 >1,024 >1,024 >1,024 >1,024 32 >128 128 4 16
249 >1,024 >1,024 >1,024 >1,024 >1,024 256 512 16 1 4 <0.06
252 >1,024 >1,024 >1,024 >1,024 >1,024 512 512 128 4 4 8
328 >1,024 >1,024 >1,024 >1,024 >1,024 8 512 >128 >128 2 32
353 >1,024 >1,024 >1,024 >1,024 >1,024 32 256 64 >128 4 32
386 >1,024 >1,024 >1,024 >1,024 >1,024 256 256 128 >128 0.5 >128
422 >1,024 >1,024 >1,024 256 >1,024 512 >1,024 >128 >128 8 128
463 >1,024 >1,024 >1,024 >1,024 >1,024 64 128 16 4 8 32
469 >1,024 >1,024 >1,024 >1,024 >1,024 64 32 >128 8 0.25 <0.06
470 >1,024 >1,024 >1,024 >1,024 >1,024 128 8 >128 >128 4 1
471 >1,024 >1,024 >1,024 >1,024 >1,024 64 8 128 4 0.25 <0.06
479 >1,024 >1,024 >1,024 >1,024 >1,024 256 1,024 64 4 0.25 0.25
499 >1,024 >1,024 >1,024 >1,024 >1,024 64 4 0.06 0.125 0.25 0.25
509 >1,024 >1,024 >1,024 >1,024 >1,024 64 1 >128 64 0.25 125
525 512 512 1,024 512 256 >1,024 >1,024 128 32 16 >128
527 1,024 512 1,024 >1,024 64 >1,024 >1,024 >128 >128 128 0.125
593 >1,024 >1,024 >1,024 >1,024 >1,024 128 64 >128 128 2 0.5
615 >1,024 >1,024 >1,024 >1,024 >1,024 >1,024 16 >128 >128 1 32
617 >1,024 >1,024 >1,024 >1,024 >1,024 >1,024 32 >128 >128 1 32
619 >1,024 >1,024 >1,024 >1,024 >1,024 >1,024 32 >128 >128 1 32

*ABK, arbekacin; AMK, amikacin; TOB, tobramycin; ISP, isepamycin; GEN, gentamicin; SM, streptomycin; NEO, neomycin; CTX,
cefotaxime; CAZ, ceftazidime; IPM, imipenem; CIP, ciprofloxacin.

†MICs of kanamycin and sisomycin are not listed because values are >1,024 for all strain numbers.
‡See Table 2 for bacterial species and PCR type of 16S rRNA methylase gene of each strain number.

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