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Volume 13, Number 4—April 2007

Research

Influenza (H5N1) Viruses in Poultry, Russian Federation, 2005–2006

Aleksandr S. Lipatov*12, Vasily A. Evseenko†1, Hui-Ling Yen*, Anna V. Zaykovskaya†, Alexander G. Durimanov†, Sergey I. Zolotykh†, Sergey V. Netesov†, Ilya G. Drozdov†, Gennadiy G. Onishchenko‡, Robert G. Webster*Comments to Author , and Alexander M. Shestopalov†

Author affiliations: *St Jude Children’s Research Hospital, Memphis, Tennessee, USA; †Federal State Research Institute Research Center for Virology and Biotechnology “Vector,” Koltsovo, Novosibirsk Region, Russian Federation; ‡Federal Service for Surveillance in Consumer Rights Protection and Human Well-being, Moscow, Russian Federation;

Main Article

Table 2

Pathogenicity and replication of influenza (H5N1) viruses in mice*

Virus Log10 EID50/mL MID50 MLD50 Titers in mouse organs
Lungs Spleen Brain Liver Kidney
A/goose/Krasnoozerskoye/627/2005
9.2
102.2
102.3
6.1±0.3
1.6±0.5
5.2±0.2
1.6±0.3
2.6±0.2
A/turkey/Suzdalka/12/2005
9.3
105.3
106.3
4.1±0.6
<1
2.3±0.5
<1
<1
A/chicken/Krasnodar/123/2006 8.4 102.1 102.3 4.7±0.3 <1 <1 <1 <1

*EID50, 50% egg infectious dose; MID50, 50% mouse infectious dose; MLD50, 50% mouse lethal dose.
†The 50% mouse infective dose (MID50) and mouse lethal dose (MLD50) are expressed as number of EID50. Values are the means of 2 titration experiments.
Mean ± SD from 3 mice, expressed as log10 EID50/0.1 mg of organ tissue.

Main Article

1These authors contributed equally to this work.

2Current affiliation: US Department of Agriculture, Athens, Georgia, USA

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