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Volume 13, Number 5—May 2007

Dispatch

Avian Influenza (H5N1) Virus in Waterfowl and Chickens, Central China

Zhengjun Yu*1, Yunfeng Song*1, Hongbo Zhou*, Xiaojuan Xu*, Qiaoyun Hu*, Haiya Wu*, Anding Zhang*, Yanjun Zhou*, Jianfeng Chen*, Hanbing Dan*, Qingping Luo*, Xiangmin Li*, Huanchun Chen*, and Meilin Jin*Comments to Author 

Author affiliations: *Huazhong Agricultural University, Wuhan, People’s Republic of China;

Main Article

Table 1

Characteristics of the 7 avian influenza (H5N1) isolates obtained in central People’s Republic of China, 2004*

HA titers Avian
Mammalian
EID50 IVPI ICPI Pathogenicity in chickens† TCID50 MLD50 Pathotype in mice‡
EWHC
210
107.5
3.0
1.91
High
104.41
101.3
High
CKDW
28
108.23
3.0
1.78
High
107.8
102.3
High
GOZF
28
109.8
2.98
1.88
High
107.35
101.5
High
CKXF
28
106.22
2.96
1.88
High
104.67
106
Medium
CKJZ
28
106.33
3.0
1.9
High
105.24
>106.5
Low
CKTM
28
107.23
1.71
1.36
High
102.0
>106.5
Low
DKXF 28 106.67 0 1.25 Low 106.57 >106.5 None

*HA, hemagglutinin; EID50, 50% egg infectious dose; IVPI, intravenous pathogenicity index; ICPI, intracerebral pathogenicity index; TCID50, 50% tissue culture infectious dose;; MLD50, 50% lethal dose in mice; EWHC, A/widgeon/Hubei/EWHC/2004; CKDW, A/chicken/Hubei/327/2004; GOZF, A/goose/Hubei/ZFE/2004; CKXF, A/chicken/Hubei/XFJ/2004; CKJZ, A/chicken/Hubei/JZJ/2004; CKTM, A/chicken/Hubei/TMJ/2004; DKXF, A/duck/Hubei/XFY/2004.
†Avian influenza virus isolates are considered to be highly pathogenic if they cause a death rate of >75% within 10 days or have an IVPI of >1.2 (World Organization for Animal Health criteria).
‡The pathotypes in mice were divided into none, low (MLD50>6.5 log10EID50), medium (3.0 log10EID50<MLD50≤6.5 log10EID50), and high (MLD50≤3.0 log10EID50).

Main Article

1Contributed equally to this article.

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