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Volume 13, Number 6—June 2007

Research

West Nile Virus Viremia in Eastern Chipmunks (Tamias striatus) Sufficient for Infecting Different Mosquitoes

Kenneth B. Platt*Comments to Author , Bradley J. Tucker*, Patrick G. Halbur*, Sonthaya Tiawsirisup†, Bradley J. Blitvich*, Flor G. Fabiosa*, Lyric C. Bartholomay*, and Wayne A. Rowley*
Author affiliations: *Iowa State University, Ames, Iowa, USA; †Chulalongkorn University, Bangkok, Thailand;

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Table 1

Histologic lesions observed in eastern chipmunks (Tamias striatus) after intramuscular inoculation with West Nile virus (WNV)

Chipmunk no. Experiment no. WNV dose* Day of death† Microscopic lesions‡/WNV antigen§¶
Brain Liver Spleen Kidney Small intestine
1 1 5.7 11 (E) −/− −/− −/− −/− −/−
2 2 3.5 2 (S) −/− −/− −/− −/− −/−
3 2 3.5 11 (E) ++/+++ +/− −/− +/+ −/−
4 2 3.5 4 (S) −/− +/++ –/+ –/+ –/+
5 2 1.5 27 (U) −/− −/− −/− −/− −/−
6 2 1.5 1 (S) −/− −/− −/− −/− −/−
7 2 1.5 14 (E) −/− −/− −/− –/+ −/−
8 3 2.6 9 (E) ++/++ +/++ −/− +/++ –/++

*Log10 PFU of WNV.
†Day of death, day postinoculation that death occurred by euthanasia (E) if a chipmunk had symptoms that prevented it from ambulating to or consuming water or food; S, death associated with sampling; U, cause of death not determined.
‡By histologic examination, lesions were not present (–), mild (+), moderate (++), or severe (+++).
§By histologic examination, WNV antigen was absent (–), mild (+), moderate (++), or extensive (+++).
¶Organs with no detectable lesions or WNV antigen included heart, lung, adrenal and salivary glands, large intestine, pancreas, and urinary bladder.

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