TY - JOUR AU - Platt, Kenneth B. AU - Tucker, Bradley J. AU - Halbur, Patrick G. AU - Tiawsirisup, Sonthaya AU - Blitvich, Bradley J. AU - Fabiosa, Flor G. AU - Bartholomay, Lyric C. AU - Rowley, Wayne A. T1 - West Nile Virus Viremia in Eastern Chipmunks (Tamias striatus) Sufficient for Infecting Different Mosquitoes T2 - Emerging Infectious Disease journal PY - 2007 VL - 13 IS - 6 SP - 831 SN - 1080-6059 AB - In eastern chipmunks (Tamias striatus) inoculated intramuscularly with 101.5 to 105.7 PFU of West Nile virus (WNV), serum titers developed sufficient to infect Aedes triseriatus (Say), Ae. vexans (Meigen), and Culex pipiens (L.). Mean titers (95% confidence interval) of 8 chipmunks were 103.9(3.3–4.5), 106.7(6.4–7.0), and 105.8(4.1–7.5) PFU/mL on days 1–3 postinoculation (p.i.) and 105.8 PFU/mL in 1 chipmunk on day 4 p.i. Mean estimated days that WNV titers were >104.8 and >105.6 were 1.7 (1.1–2.3) and 1.4 (1.0–1.6). The longest period of viremia >104.8 PFU/mL was 3–4 days. WNV antigen was detected in the small intestine of 2 chipmunks and the kidneys of 4 chipmunks by immunohistochemistry. WNV also was detected in urine, saliva, and feces of some chipmunks. These data suggest chipmunks might play a role in enzootic WNV cycles and be an amplifying host for mosquitoes that could infect humans. KW - West Nile virus KW - chipmunks KW - Aedes triseriatus KW - Aedes vexans KW - Culex pipiens KW - research KW - United States DO - 10.3201/eid1306.061008 UR - https://wwwnc.cdc.gov/eid/article/13/6/06-1008_article ER - End of Reference