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Volume 13, Number 8—August 2007

Research

Infection with Scedosporium apiospermum and S. prolificans, Australia

Louise Cooley*†, Denis Spelman*, Karin Thursky‡, and Monica Slavin*‡Comments to Author 
Author affiliations: *Alfred Hospital, Prahran, Victoria, Australia; †Royal Hobart Hospital, Hobart, Tasmania, Australia; ‡Royal Melbourne Hospital, Parkville, Victoria, Australia;

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Table 2

Characteristics of 8 patients with invasive disease and Scedospoeium prolificans infections, Australia, 1997–2003*

Patient no.Primary diseaseTransplant typeNeutropenia within 30 dGVHDDate of first isolateDays
post transplantInitial symptomSite of 
isolatesOutcome following diagnosis
1ALLAllogeneic HSCTYesChronic extensiveAug 
2000>400Knee effusionBlood, 
synovium, cartilage, prostateDied d 21
2AMLAllogeneic HSCTNoChronic extensiveApr 
2001>500Pulmonary 
infiltrateBlood, sputum, BAL, lungDied d 5
3MMAllogeneic HSCTYesNoNov 
200028Ethmoid sinus infiltrateEthmoid sinus, vertebral disc, mycotic aneurysmAlive d 500
4NHLAllogeneic HSCTYesNoDec 
200010Neutropenic 
sepsisBloodDied before diagnosis
5AMLAllogeneic HSCTYesNoMar 
200310Neutropenic 
sepsisBlood, sputum, BAL, lung, skinDied d 1
6MMAllogeneic HSCTYesChronic extensiveNov 
2002120PneumoniaSputumDied d 1
7MDSNANoNANov 
2003NAMaxillary sinus infiltrateSputum, maxillary sinus, pericardium, myocardium, kidney, skin, 
lungDied d 14
8AMLNAYesNAMay 2002NACatheter-related sepsisChest wall, Hickman catheterAlive d 500

*GVHD, graft versus host disease; ALL, acute lymphoblastic leukemia; HSCT, hematopoietic stem cell transplantation; AML, acute myeloid leukemia; BAL, bronchoalveolar lavage; MM, multiple myeloma; NHL, non-Hodgkin lymphoma; MDS, myelodysplastic syndrome; NA, not applicable because patients did not undergo stem cell transplantation.

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