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Volume 13, Number 9—September 2007

Dispatch

Buruli Ulcer Surveillance, Benin, 2003–2005

Ghislain Emmanuel Sopoh*Comments to Author , Roch Christian Johnson†, Annick Chauty‡, Ange Dodji Dossou*§, Julia Aguiar¶, Olivier Salmon#, Françoise Portaels**, and Kingsley Asiedu††
Author affiliations: *Centre de Dépistage et de Traitement de l’Ulcère de Buruli, d’Allada, Bénin; †Programme National de Lutte contre l’Ulcère de Buruli, Cotonou, Bénin; ‡Centre de Dépistage et de Traitement de l’Ulcère de Buruli de Pobè, Pobè, Bénin; §Centre de Dépistage et de Traitement de l’Ulcère de Buruli de Lalo, Lalo Bénin; ¶Centre Sanitaire et Nutritionnel Gbemontin, Zagnanado, Bénin; #Hôpital “La Croix,” de Zinvié, Bénin; **Institut de Médecine Tropicale, Antwerp, Belgium; ††World Health Organization, Geneva, Switzerland

Suggested citation for this article

Abstract

We reviewed Buruli ulcer (BU) surveillance in Benin, using the World Health Organization BU02 form. We report results of reliable routine data collected on 2,598 new and recurrent cases from 2003 through 2005.

Buruli ulcer (BU), a disease caused by Mycobacterium ulcerans, is one of the recently classified 13 neglected tropical diseases (1). It has been reported in >30 countries (2). The disease starts as a nonulcerative lesion-like nodule, plaque, or edema. Without treatment, these early lesions will progress to an ulcer. The disease affects the bone in an estimated 13% of patients (3). Treatment often requires multiple interventions, including specific antimicrobial agents, surgery, and physiotherapy. Recurrence is high in many countries (4,5), and the economic effects on affected households, communities, and the health system are considerable (6,7). The exact mode of transmission of the causative organism is not known. The only known risk factors are related to water, particularly the use of unsafe water (8), especially that obtained from swamps (9).

We describe Benin’s surveillance system for BU from 2003 through 2005. The system is based on the use of the World Health Organization (WHO) BU02 form.

The Study

The study took place in Benin, West Africa. The BU control activities are organized by a National Control Programme. Five BU Detection and Treatment Centers (CDTUB) are distributed throughout the BU-endemic regions. The detection, referral, and follow-up of BU cases rely heavily on community-based surveillance teams composed of village volunteers and 1 or 2 teachers and supervised by health workers from the nearest health facility.

The BU02 form acts as a triple registry. A trained nurse registers each case on the form. Each quarter, the completed first sheet is sent to the national level. The second sheet is sent to the regional level, and the third is kept at the CDTUB for local analysis. A training workshop is performed annually for the surveillance team. At the national level, data are computerized for analysis and mapping, and feedback is provided annually at a review meeting with all BU management participants.

With the use of this system, from January 1, 2003, through December 31, 2005, a total of 2,598 new and recurrent cases were reported and treated in Benin (Tables 1 and 2). The rates of disease recurrence (6%) were much lower than the figures reported in other countries, e.g., 16% in Ghana (4,5). Euverte found a rate of 3% recurrence among 103 patients treated with streptomycin and rifampin in Oueme, Benin, in 2005 (6). During the same period, the total numbers of leprosy and tuberculosis cases were 1,163 and 8,556, respectively. Thus, BU has become the second most important mycobacterial disease after tuberculosis in some endemic countries, including Benin (3) and Ghana (7).

Consistent with other studies (10), our study found that 51% of the 2,598 cases were in children <15 years of age. Cases were equally distributed between male (49.7%) and female (50.3%) patients.

Of the total case-patients, 1,644 (63.3%) reported lesions on their lower limbs; 524 (20.2%), lesions on their upper limbs; 231 (8.9%), lesions on their head, neck, or trunk; 19 (0.7%), lesions in the perineal region; and 160 (6.2%), lesions in multiple areas. The location of a lesion was not noted on the BU02 form for 20 (0.8%) case-patients.

Many researchers believe that because legs and arms are the most exposed parts of the body they are more likely to be injured or to be bitten by an insect that may be associated with transmission of M. tuberculosis. However, why some lesions occur in the perineum, which is the least exposed area, remains unclear. In some villages, persons take baths in the swamps while carrying out domestic activities such as washing clothes or dishes. Lesions around the head, neck, and trunk were present in 9% of patients and in the perineum in almost 1%. Although these percentages are small, managing the technical and cosmetic aspects of lesions in the head, neck (11), and perineal regions (12) is difficult in Benin, where plastic surgeons are not available.

Nonulcerative early lesions (nodule, edema, and plaques) occurred in 27% of the total cases. Ulcers and mixed forms (an ulcer and some other form of the disease) occurred in 72% of the cases, and single ulcerative lesions occurred in 54%. The clinical form was not properly recorded for 2% of cases. Our figure of 72% is lower than the 94% rate reported elsewhere for Benin from 1989 through 1996 (13). The real challenge in Benin is how to further reduce the percentage of ulcers and sustain such surveillance efforts.

Regarding infection involving bone, Debacker et al. (3) reported a rate of 13% among 1,700 patients treated at CDTUB Zagnanado from 1997 through 2001. However, our results showed that bone involvement occurred in 6% of cases. Bone infection is a consequence of late disease (14). As progress is made in reducing late disease, bone lesions should be reduced.

Laboratory confirmation of BU is not frequently performed before treatment is begun. Although WHO strongly recommends laboratory confirmation of cases, in practice not all cases require it. Our study shows that 50% of cases are confirmed by at least 1 laboratory method under routine conditions.

Appendix Figure 1

Thumbnail of Distribution of Buruli ulcer cases at regional and village levels, Benin.

Appendix Figure 1. Distribution of Buruli ulcer cases at regional and village levels, Benin.

Appendix Figure 2

Thumbnail of Concentration of Buruli ulcer cases along the major Benin rivers, the Oueme and Couffo.

Appendix Figure 2. Concentration of Buruli ulcer cases along the major Benin rivers, the Oueme and Couffo.

The geographic distribution of cases shows that the BU-endemic areas are confined to the southern half of the country, Most BU-endemic villages occur along the Oueme and Couffo Rivers (Appendix Figure 1, and Appendix Figure 2).

The Mono Region has the lowest incidence of BU in southern Benin. By contrast, the other BU-endemic regions are around rivers. This observation cannot be due to insufficiency of reporting because there is a CDTUB in the area and surveillance is good (Appendix Figure 1). Unlike previous reports from Benin, our results suggest that the Oueme Region is now the most endemic for BU, not the Zou Region (Appendix Figure 1). We believe that this finding may be due to the active community-level detection and antimicrobial drug treatment conducted by the new BU center established in the Ouémé/Plateau region in April 2004.

Conclusions

The data provided by Benin’s BU surveillance system that used the BU02 form enabled the BU Program in Benin to reliably describe the epidemiologic situation, evaluate the results of actions, measure the results of the centers, and plan future interventions. The collected data are ≈98% complete. We conclude that the BU surveillance system is useful to the BU Program in Benin. Because the BU02 form has 3 parts, data can be submitted from the field without the difficulties of photocopying the pages of the register or entering the data in a computer, which may be problematic at a rural facility level. However, training and supervision of health workers are required.

Dr Sopoh is medical director of Buruli Ulcer Treatment Center, Allada, Benin. He is also a doctoral student at the Institute of Tropical Medicine Antwerp. His primary research interests are public health aspects of the management of BU, including prevention, surveillance, and treatment.

Acknowledgments

We are grateful to all the staffs of the CDTUBs involved in data collection.

The CDTUBs and Benin’s surveillance system are supported by many partners and organizations, in particular, the government of Benin, WHO, General Direction for Development and Cooperation, Raoul Follereau Foundation of Luxembourg, Raoul Follereau Association of France, and the nongovernmental organization Anesvad – Burulico Project (European Union)

References

  1. Molyneux DH, Hotez PJ, Fenwick A. “Rapid-impact interventions”: how a policy of integrated control for Africa’s neglected tropical diseases could benefit the poor. PLoS Med. 2005;2:e336. Epub 2005 Oct 11. DOIPubMed
  2. World Health Organization. Buruli ulcer: Mycobacterium ulcerans infection. Geneva: the Organization; 2000.
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  4. Amofah G, Asamoah S, Afram-Gyening C. Effectiveness of excision of pre-ulcerative Buruli lesions in field situations in a rural district in Ghana. Trop Doct. 1998;28:813.PubMed
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  12. Sica A, Dekou A, Kaba L, Ouattara D, Kouame B, Konan PG, Genital sites of Buruli ulcer (BU): clinical and therapeutic aspects. Prog Urol. 2005;15:7368.PubMed
  13. Aguiar J, Domingo MC, Guedenon A, Meyers WM, Steunou C, Portaels F. L’ulcère de Buruli, une maladie mycobactérienne importante et en recrudescence au Bénin. ARSOM Bulletin des Séances. 1997;3:32556.
  14. Portaels F, Zinsou C, Aguiar J, Debacker M, de Biurrun E, Guedenon A, Les atteintes osseuses dans l’ulcère de Buruli: à propos de 73 cas. Bull Seances Acad R Sci Outre Mer. 2003;49:16190.

Figures

Tables

Suggested citation for this article: Sopoh GE, Johnson RC, Chauty A, Dossou AD, Aguiar J, Salmon O, et al. Buruli ulcer surveillance, Benin, 2003–2005. Emerg Infect Dis [serial on the Internet]. 2007 Sep [date cited]. Available from http://wwwnc.cdc.gov/eid/article/13/9/06-1338.htm

DOI: 10.3201/eid1309.061338

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