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Volume 13, Number 9—September 2007

Dispatch

Fecal Viral Concentration and Diarrhea in Norovirus Gastroenteritis

Nelson Lee*, Martin C.W. Chan*, Bonnie Wong*, K.W. Choi*, Winnie Sin*, Grace Lui*, Rickjason C. W. Chan*, Raymond W.M. Lai*, C.S. Cockram*, Joseph J.Y. Sung*, and Wai K. Leung*Comments to Author 
Author affiliations: *Prince of Wales Hospital, Hong Kong Special Administrative Region, People’s Republic of China;

Main Article

Table

Fecal viral concentrations of 40 patients infected with norovirus*

Comparison groups (%) Median fecal viral concentration, log10 copies cDNA/g stool (IQR) p value
Age, y
<65 (47.5) 8.48 (7.79–10.11) 0.064
>65 (52.5) 8.97 (8.54–10.70)
Sex
Male (37.5) 8.97 (7.79–10.72) 0.706
Female (62.5)
8.88 (8.24–10.22)
Pre-existing medical conditions†
No (57.5) 8.95 (7.86–10.26) 0.520
Yes (42.5) 8.91 (8.31–10.14)
Diarrhea duration‡
Limited (62.2) 8.38 (7.89–9.45) 0.001
Prolonged (37.8)
10.49 (8.84–10.94)
Vomiting
No (35.1) 8.71 (7.71–9.91) 0.215
Yes (64.9) 9.10 (8.25–10.40)
Fever§
No (62.2) 8.77 (8.15–10.17) 0.380
Yes (36.8) 9.13 (8.23–10.75)

*IQR, interquartile range.
†Includes diabetes mellitus, chronic cardiovascular/pulmonary/hepatic diseases, and underlying malignancies. No patient had conditions associated with profound immunosuppression in this cohort.
‡Limited (62.2%) is defined as a total duration of diarrhea of 1–3 d, including both hospitalized and nonhospitalized patients (followed up by the same hospital’s emergency departments as outpatients).Prolonged (37.8%) is defined as a total duration of diarrhea >4 d; all but 1 were hospitalized patients.
§Temperature >37.5°C on >1 occasion.

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