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Volume 14, Number 1—January 2008
THEME ISSUE
International Polar Year

Dispatch

Molecular Epidemiology of Dengue Virus Strains from Finnish Travelers

Eili Huhtamo*Comments to Author , Nathalie Y. Uzcátegui*, Heli Siikamäki†, Auli Saarinen*, Heli Piiparinen*, Antti Vaheri*, and Olli Vapalahti*‡§
Author affiliations: *Haartman Institute, University of Helsinki, Finland; †Helsinki University Central Hospital, Finland; ‡HUSLAB Hospital District of Helsinki and Uusimaa, Finland; §Faculty of Veterinary Medicine, University of Helsinki, Finland;

Main Article

Table

Dengue virus isolates from Finnish travelers, 2000–2005*

Virus serotype Patient travel history Year Isolate/ case no. Strain designation (GenBank accession
 no.) IFA screening of infected cells†
Isolation serum antibody status
Patient sex/ age, y
Vero E6
C6/36
dpi Pos dpi Pos dpo IgM IgG
DENV-1 Thailand 2002 3 F9.D1.02
(EU005250) 7 +++ 7 ++ 5 <10 F/23
DENV-1 Malaysia/ Thailand 2002 4 F12.D1.02
(EU005249) 24 + 7 + 20 F/43
DENV-1 Thailand 2005 8 F31.D1.05
(EU005248) 24 + 7 + <10 F/56
DENV-1 India 2005 11 F37.D1.05
(EU005247) 5 +++ 5 +++ 3 NA NA M/31
DENV-2 Sri Lanka 2003 6 F18.D2.03
(EU005252) 24 + 5 + 320 M/54
DENV-2 Ghana 2005 9 F32.D2.05
(C-preM, EU005251;
E, EU005258) 7 +++ 7 + 2 + <10 F/22
DENV-3 Cuba 2002 2 F7.D3.02
(EU005253) 7 + 24 + 6 + 20 M/55
DENV-3 Brazil 2003 5 F13.D3.03
(EU005254) 24 + 5 + <20 M/26
DENV-3 Sri Lanka 2004 7 F24.D3.04
(EU005255) 4 +++ 24 + 2 20 F/39
DENV-4 Sri Lanka 2000 1 F2.D4.00
(EU005256) 10 +++ 10 + 4 + <10 F/42
DENV-4 Indonesia 2005 10 F34.D4.05
(EU005257) 24 + 5 + 20 M/37

*IFA, immunofluoresence assay; dpi, day postinfection; Pos, proportion of positive cells; dpo, day post-onset; Ig, immunoglobulin; DENV, dengue virus; NA, not available; c-preM, capsid–premembrane; E, envelope.
† +, ++, and +++ indicate the relative amount of positive cells observed in IFA using fluorescence microscope: individual positive cells observed <10% (+), 10–50% of the cells positive (++), 50%–100% of the cells positive (+++). –, not detected.

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