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Volume 14, Number 10—October 2008
Research

Cryptosporidium Species and Subtypes and Clinical Manifestations in Children, Peru

Vitaliano A. Cama, Caryn Bern, Jacqueline Roberts, Lilia Cabrera, Charles R. Sterling, Ynes Ortega, Robert H. Gilman, and Lihua XiaoComments to Author 
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (V.A. Cama, C. Bern, J. Roberts, L. Xiao); Asociacion Benefica Proyectos en Informática, Salud, Medicina y Agricultura, Lima, Peru (L. Cabrera); University of Arizona, Tucson, Arizona, USA (C.R. Sterling); University of Georgia, Griffin, Georgia, USA (Y. Ortega); The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA (R.H. Gilman);

Main Article

Table 5

Associations between infections with Cryptosporidium spp. or C. hominis subtype families and clinical manifestations expressed as incidence rate ratios in 533 children, Peru*

Clinical manifestation First infection
 All infections
IRR p value IRR p value
Children infected with C. hominis vs. those with cryptosporidiosis but not infected with C. hominis
Nausea 5.469 <0.001† 3.531 0.037‡
Vomiting 2.252 <0.001† 2.359 0.023‡
General malaise 2.523 <0.001† 2.071 0.035‡
Diarrhea
 3.690
 <0.001†
4.886
 <0.001†
Children infected with C. parvum vs. those with cryptosporidiosis but not infected with C. parvum
Diarrhea
 3.249
 <0.001†
4.562
 <0.01†
Children infected with C. meleagridis vs. those with cryptosporidiosis but not infected with C. meleagridis
Diarrhea
 2.484
 0.006†
7.684
 <0.001†
Children infected with C. canis or C. felis vs. those with cryptosporidiosis but not infected with these species
Diarrhea
 3.122
 0.002†
1.528
 0.662
Children infected with C. hominis subtype family Ia vs. those not infected with that subtype family
Nausea 5.020 <0.001† 3.203 0.183
Vomiting 2.280 0.013‡ 2.100 0.141
Diarrhea
 2.442
 <0.001†
3.061
 0.002†
Children infected with C. hominis subtype family Ib vs. those not infected with that subtype family
Nausea 12.516 <0.001† 8.402 0.006†
Vomiting 4.752 <0.001† 4.868 0.004†
General malaise 4.939 <0.001† 4.139 0.006†
Diarrhea
 5.510
 <0.001†
6.506
 <0.001†
Children infected with C. hominis subtype family Id vs. those not infected with that subtype family
Diarrhea
 2.999
 <0.001†
3.171
 0.022‡
Children infected with C. hominis subtype family Ie vs. those not infected with that subtype family
General malaise 1.830 0.010‡ 1.613 0.333
Diarrhea 3.117 <0.001† 4.160 0.001†

*Determined by Poisson regression analyses. IRR, incidence rate ratio.
†Statistically significant at Bonferroni corrected α = 0.01.
‡Statistically significant at p<0.05.

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Page created: July 13, 2010
Page updated: July 13, 2010
Page reviewed: July 13, 2010
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