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Volume 14, Number 10—October 2008

CME ACTIVITY - Research

Microbial Interactions during Upper Respiratory Tract Infections

Melinda M. PettigrewComments to Author , Janneane F. Gent, Krystal Revai, Janak A. Patel, and Tasnee Chonmaitree
Author affiliations: Yale School of Public Health, New Haven, Connecticut, USA (M. Pettigrew, J. Gent); University of Texas Medical Branch, Galveston, Texas, USA (K. Revai, J. Patel, T. Chonmaitree);

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Table 2

Distribution of bacteria on nasopharyngeal swabs collected from children with URI, University of Texas Medical Branch, Galveston, Texas, USA, 2003–2007*

Variable Total no. (%) URI visits No. (%) URI visits†
1 2 3–4 5–6 >6
Total no. patients 212 46 (21.7) 42 (19.8) 38 (17.9) 37 (17.4) 49 (23.1)
Total no. swabs
968
46 (4.8)
84 (8.7)
128 (13.2)
201 (20.8)
509 (52.6)
Bacteria present (% of no. of swabs in each visit category)
0 127 (13.1) 9 (19.6) 9 (10.7) 13 (10.2) 19 (9.4) 77 (15.1)
1
Streptococcus pneumoniae 79 (8.2) 1 ( 2.2) 9 (10.7) 15 (11.7) 20 (10.0) 34 (6.7)
Haemophilus influenzae 86 (8.9) 7 (15.2) 10 (11.9) 11 (8.6) 18 (9.0) 40 (7.9)
Moraxella catarrhalis 201 (20.8) 10 (21.7) 12 (14.3) 27 (21.1) 41 (20.4) 111 (21.8)
Staphylococcus aureus 24 (2.5) 1 (2.2) 2 (2.4) 2 (1.6) 3 (1.5) 16 (3.1)
2
S. pneumoniae, H. influenzae 28 (2.9) 1 (2.2) 2 (2.4) 4 (3.1) 8 (4.0) 13 (2.6)
S. pneumoniae, M. catarrhalis 187 (19.3) 13 (28.3) 20 (23.8) 24 (18.8) 36 (17.9) 94 (18.5)
S. pneumoniae, S. aureus 8 (0.8) 0 1 (1.2) 1 (1.0) 4 (2.0) 2 (0.4)
H. influenzae, M. catarrhalis 67 (6.9) 2 (4.4) 5 (6.0) 7 (5.5) 13 (6.5) 40 (7.9)
H. influenzae, S. aureus 3 (0.3) 0 1 (1.2) 0 1 (0.5) 1 (0.2)
M. catarrhalis, S. aureus 17 (1.8) 0 2 (2.4) 3 (2.3) 2 (1.0) 10 (2.0)
3
S. pneumoniae, H. influenzae, M. catarrhalis 124 (12.8) 2 (4.4) 8 (9.5) 19 (14.8) 31 (15.4) 64 (12.6)
S. pneumoniae, H. influenzae, S. aureus 2 (0.2) 0 1 (1.2) 0 0 1 (0.2)
S. pneumoniae, M. catarrhalis, S. aureus 11 (1.1) 0 1 (1.2) 2 (1.6) 4 (2.0) 4 (0.8)
H. influenzae, M. catarrhalis, S. aureus 2 (0.2) 0 0 0 1 (0.5) 1 (0.2)
4 2 (0.2) 0 1 (1.2) 0 0 1 (0.2)

*URI, upper respiratory tract infection.
†Data are presented as no. of physician visits/child. Because of our prospective study design, many children had >1 URI episode during the follow-up period, and some had >1 physician visit/URI episode. One nasopharyngeal swab sample was taken at each physician visit.

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