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Volume 14, Number 11—November 2008

Dispatch

Phylogenetics and Pathogenesis of Early Avian Influenza Viruses (H5N1), Nigeria

Comfort O. Aiki-Raji1, Patricia V. Aguilar1, Yong-Kuk Kwon, Sue Goetz, David L. Suarez, Aashish I. Jethra, Oyekanmi Nash, Christopher A.O. Adeyefa, Festus D. Adu, David Swayne, and Christopher F. BaslerComments to Author 
Author affiliations: University of Ibadan, Ibadan, Nigeria (C.O. Aiki-Raji, O. Nash, C.A.O. Adeyefa, F.D. Adu); Mount Sinai School of Medicine, New York, New York, USA (P.V. Aguilar, A.I. Jethra, C.F. Basler); US Department of Agriculture, Athens, Georgia, USA (Y.-K. Kwon, S. Goetz, D.L. Suarez, D. Swayne);

Main Article

Table

Virus isolation titers from chickens inoculated with highly pathogenic influenza A/chicken/Nigeria/228-5/2005 (H5N1) and controls*

Sample
Virus-positive swabs/swabs tested, 
no. (mean titer† as log10 EID50/mL)

Virus-positive tissues/tissues tested, no. (mean titer† as log10 EID50/g)
Oropharyngeal
Tracheal
Heart
Kidney
Lung
Muscle
Brain
Sham 0/2 0/2 0/2 0/2 0/2 0/2 0/2
Experimental
1 dpi 2/2 (2.4) 1/2 (1.7) 1/2 (2.9) 1/2 (4.5) 1/2 (4.9) 1/2(3.9) 1/2 (3.5)
2 dpi 2/2 (6.1) 2/2 (6.8) 2/2 (8.7) 2/2 (7.9) 2/2 (7.6) 2/2 (6.8) 2/2 (5.6)

*Virus isolated from tissues and swabs sample on 1 and 2 days postinoculation (dpi). EID50, mean embryo infectious doses.
†Limit of detection <101.9 EID50/g of tissue or <100.9 EID50/mL sample.

Main Article

1These authors contributed equally to this work.

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