TY - JOUR AU - Chesson, Harrell W. AU - Ekwueme, Donatus U. AU - Saraiya, Mona AU - Markowitz, Lauri E. T1 - Cost-effectiveness of Human Papillomavirus Vaccination in the United States T2 - Emerging Infectious Disease journal PY - 2008 VL - 14 IS - 2 SP - 244 SN - 1080-6059 AB - We describe a simplified model, based on the current economic and health effects of human papillomavirus (HPV), to estimate the cost-effectiveness of HPV vaccination of 12-year-old girls in the United States. Under base-case parameter values, the estimated cost per quality-adjusted life year gained by vaccination in the context of current cervical cancer screening practices in the United States ranged from $3,906 to $14,723 (2005 US dollars), depending on factors such as whether herd immunity effects were assumed; the types of HPV targeted by the vaccine; and whether the benefits of preventing anal, vaginal, vulvar, and oropharyngeal cancers were included. The results of our simplified model were consistent with published studies based on more complex models when key assumptions were similar. This consistency is reassuring because models of varying complexity will be essential tools for policy makers in the development of optimal HPV vaccination strategies. KW - human papillomavirus KW - vaccine KW - cost-effectiveness KW - research KW - United States DO - 10.3201/eid1402.070499 UR - https://wwwnc.cdc.gov/eid/article/14/2/07-0499_article ER - End of Reference