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Volume 14, Number 2—February 2008

Letter

Plasmid-mediated Quinolone Resistance in Salmonella enterica, United Kingdom

Katie L. Hopkins*Comments to Author , Martin Day*, and E. John Threlfall*
Author affiliations: *Health Protection Agency Centre for Infections, London, United Kingdom;

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Table

Isolates of Salmonella enterica with plasmid-mediated qnr genes, United Kingdom, October 2006–April 2007

Salmonella serotype Phage type* No. isolates VNTR profile† Ciprofloxacin MIC (μg/mL)‡ Additional resistance to antimicrobial drugs§ qnr identified
Corvallis 1 0.25 S, Su, T qnrS1
Corvallis 2 0.38 S, Su, T qnrS1
Corvallis 1 1.0 S, Su, T ,Cf qnrS1
Corvallis 1 0.25 None qnrS1
Corvallis 1 0.38 None qnrS1
Schwarzengrund 1 0.25 T qnrB5
Typhimurium DT120 4 1–6-0–0-3 0.38 S, Su, T qnrS1
Typhimurium DT120 3 1–6-0–0-3 0.50 S, Su, T qnrS1
Typhimurium DT120 3 1–4-0–0-3 0.38 S, Su, T qnrS1
Typhimurium DT120 1 1–4-0–0-3 0.50 S, Su, T qnrS1
Typhimurium DT120 1 1–4-0–0-3 0.38 None qnrS1
Typhimurium DT120 1 1–5-0–0-3 0.38 S, Su, T qnrS1
Typhimurium DT193 1 1–6-0–0-3 0.50 S, Su, T qnrS1
Typhimurium DT193 1 1–4-0–0-3 0.38 C, S, Su, Sp, T, Tm qnrS1
Typhimurium DT193 1 1–4-0–0-3 0.38 S, Su, T qnrS1
Typhimurium DT193 2 1–5-0–0-3 0.38 S, Su, T qnrS1
Typhimurium DT193 1 1–4-0–0-3 0.50 A, Su qnrS1
Typhimurium 49b 1 1–4-19–1-3 0.25 A, G, Ne, K, S, Su, Sp, T, Tm, Ak, Cx, Cr, Cf, Cn, Ct qnrB2
Typhimurium NC 1 1–4-0–0-3 0.25 S, Su, T qnrS1
Typhimurium UT 1 3–8-19–1-2 >32 A, C, G, S, Su, Sp, T, Tm, Fu, Nx qnrS1
Virchow 43 5 1.0 A, Fu, Nx qnrS1
Virchow 43 2 1.5 A, Fu, Nx qnrS1
Virchow 25a 1 0.75 Tm qnrS1
Virchow 11 1 1.0 A, Fu, Nx qnrS1
Virchow NC 1 1.5 A, C, G, Ne, K, S, Su, Sp, T, Tm, Fu, Nx, Cx, Cr, Cf, Cn, Ct qnrS1

*DT, definitive type; NC, does not conform to a recognized pattern; UT, untypeable.
†VNTR, variable number tandem repeat. Loci of the VNTR profiles are presented in the following order: STTR9-STTR5-STTR6-STTR10pl-STTR3. The number 0 in the VNTR profile represents cases with no amplification of PCR product.
‡Determined by Etest.
§Antimicrobial drugs (breakpoint final concentrations): S, streptomycin (16 mg/L); Su, sulfonamide (64 mg/L); T, tetracycline (8 mg/L); Cf, cefuroxime (16 mg/L); C, chloramphenicol (8 mg/L); Sp, spectinomycin (64 mg/L); Tm, trimethoprim (2 mg/L); A, ampicillin (8 mg/L]; G, gentamicin (4 mg/L); Ne, neomycin (8 mg/L) K, kanamycin (8 mg/L); Ak, amikacin (4 mg/L); Cx, cefalexin (16 mg/L); Cr, cefradine (16 mg/L); Cn, ceftriaxone (1 mg/L); Ct, cefotaxime (1 mg/L); Fu, furazolidone (8 mg/L); Nx, nalidixic acid (16 mg/L).

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