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Volume 14, Number 4—April 2008
Research

Determination of Oseltamivir Quality by Colorimetric and Liquid Chromatographic Methods

Michael D. Green*Comments to Author , Henry Nettey*, and Robert A. Wirtz*
Author affiliations: *Centers for Disease Control and Prevention, Atlanta, Georgia, USA;

Main Article

Table 2

Evaluation of oseltamivir products purchased over the Internet*

Brand HPLC Congo red Bromochlorophenol blue
A 94 ± 1 95 ± 3 106 ± 4
B 87 ± 2 88 ± 3 97 ± 8
C 94 ± 4 93 ± 2 103 ± 3
D 96 ± 1 93 ± 5 107 ± 7
E 97 ± 3 89 ± 3 104 ± 5
F 95 ± 0 88 ± 2 101 ± 3

*HPLC, high-performance liquid chromatography. Values are the percentage of active ingredient found per capsule relative to that stated on the manufacturer’s package insert (average ±SD; n = 3 capsules).

Main Article

Page created: July 09, 2010
Page updated: July 09, 2010
Page reviewed: July 09, 2010
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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