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Volume 14, Number 4—April 2008

Research

Seroprevalence and Risk Factors for Human Herpesvirus 8 Infection, Rural Egypt1

Sam M. Mbulaiteye*Comments to Author , Ruth M. Pfeiffer*, Bryan Dolan*, Victor C.W. Tsang†, John Noh†, Nabiel N.H. Mikhail‡, Mohamed Abdel-Hamid§¶, Mohamed Hashem§¶, Denise Whitby#, G. Thomas Strickland¶, and James J. Goedert*
Author affiliations: *National Cancer Institute, Bethesda, Maryland, USA; †Centers for Disease Control and Prevention, Atlanta, Georgia, USA; ‡Assiut University, Cairo, Egypt; §National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt; ¶University of Maryland School of Medicine, Baltimore, Maryland, USA; #National Cancer Institute-Frederick, Frederick, MD, USA;

Main Article

Table 1

Prevalence and crude OR of association of HHV-8 seropositivity with demographic, behavioral, and clinical characteristics among male patients, Egypt*

Characteristic
n/N
%
OR
95% CI
p value†
Total 52/235 22.1
Age group, y <0.001
15–24 8/96 8.3 Ref
25–34 16/54 29.6 4.6 2.0–11.0
35–44 10/30 33.3 5.5 1.9–15.7
>45
18/55
32.7
5.3
2.2–13.2

Education 0.001
None 19/50 38.0 Ref
Primary 22/100 22.0 0.5 0.2–1.0
Secondary/postsecondary
11/85
12.9
0.2
0.1–0.6

Job 0.001
Student 2/38 5.3 Ref
Not working 6/31 19.3 4.3 0.8–23.3
Farmer 25/87 28.7 7.3 1.6–32.4
Trade, service, production 13/63 20.6 4.7 1.1–20.0
Technician/secretary
6/16
37.5
10.8
1.9–61.3

Marital status 0.004
Not married 11/91 12.1 Ref
Married 39/136 28.7 3.1 1.4–6.5
Separated/divorced/widowed
2/8
25.0
7.6
1.0–60.8

Dental treatments <0.001
No 16/128 12.5 Ref
Yes
36/107
33.6
3.5
1.8–7.1

Tattoos 0.53
No 50/220 22.7 Ref
Present
2/15
13.3
0.5
0.1–2.5

HCV serostatus 0.72
Negative 48/214 22.4 Ref
Positive
4/21
19.0
0.8
0.3–2.5

Injections (lifetime) 0.74
<10 20/72 20.8 Ref
>10
37/163
22.7
1.1
0.6–2.1

Smoking 0.02
Never 23/138 16.7 Ref
Ever
29/97
29.9
2.1
1.1–4.0

Goza‡ 0.77
Never 42/193 21.8 Ref
Ever
10/42
23.8
1.1
0.5–2.4

Schistosomiasis 0.43
Negative 1/9 11.1 Ref
Positive 51/226 31.0 2.3 0.3–19.0

*OR, odds ratio; HHV-8, human herpesvirus 8; CI, confidence interval; Ref, referrent; HCV, hepatitis C virus.
†p value for age group and education is test for trend; otherwise, p value is test for heterogeneity
‡Goza is a method of tobacco smoking in which tobacco smoke passes through a water pipe.

Main Article

1Results were presented, in part, at the 9th International Workshop on Kaposi’s Sarcoma–associated Herpesvirus (KSHV) and Related Agents, Cape Cod, Massachusetts, USA, July 12–15, 2006.

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